Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis

被引：17
|
作者：
Gonzalez-Gay, Miguel A. [1 ]
Gonzalez-Juanatey, Carlos [2 ]
机构：
[1] Hosp Univ Marques de Valdecilla, IFIMAV, Dept Rheumatol, E-39008 Santander, Spain
[2] Hosp Lucus Augusti, Div Cardiol, Lugo 27003, Spain
来源：
ARTHRITIS RESEARCH & THERAPY | 2012年 / 14卷 / 04期
关键词：
ACCELERATED ATHEROGENESIS; DISEASE;
D O I：
10.1186/ar3891
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Different techniques have proven to be useful in determining the presence of subclinical cardiovascular disease in patients with rheumatoid arthritis (RA). Doppler imaging with iontophoresis of acetylcholine and flow-mediated, endothelium-dependent vasodilation give information on endothelial dysfunction, an early step in the atherogenesis process. However, there is no good correlation between these two surrogate markers of cardiovascular disease in RA. A single determination of routine laboratory markers of inflammation does not seem to relate to endothelial function in RA. Further research is needed to determine whether microvascular endothelial function is a better predictor of cardiovascular outcome than macrovascular endothelial function in patients with RA.
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页数：2
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