Conformationally locked nucleosides.: Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′-C-bridged 2′-deoxynucleosides

被引：71

作者：

Wang, GY ^{[1
]}

Gunic, E ^{[1
]}

Girardet, JL ^{[1
]}

Stoisavljevic, V ^{[1
]}

机构：

[1] ICN Pharmaceut Inc, Res Dept, Costa Mesa, CA 92626 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00146-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A conformationally locked, 2',4'-C-bridged 2'-deoxyribofuranoside(2) was condensed with silylated pyrimidines to give 2',4'-C-bridged bicyclonucleosides, which were converted to the phosphoramidites and incorporated into oligodeoxynucleotides (ODNs). The hybridization data of the modified ODNs to DNA and RNA are presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1147 / 1150

页数：4

共 50 条

[1] Conformationally locked nucleosides.: Synthesis and stereochemical assignments of 2′-C,4′-C-bridged bicyclonucleosides
Wang, GY
Girardet, JL
Gunic, E
TETRAHEDRON, 1999, 55 (25) : 7707 - 7724
[2] Conformationally locked nucleoside analogs.: Synthesis of 2′-deoxy-2′-C, 4′-C-bridged bicyclic nucleosides
Wang, GY
Gunic, E
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1999, 18 (4-5): : 531 - 536
[3] Conformationally locked nucleosides.: Synthesis and stereochemical assignments of 3′-N,5′-C-bridged 3′-amino-3′-deoxythymidines
Wang, GY
TETRAHEDRON LETTERS, 1999, 40 (35) : 6343 - 6346
[4] Conformationally locked nucleosides.: Synthesis of oligodeoxynucleotides containing 3′-amino-3′-deoxy-3′-N,5′ (R)-C-ethylenethymidine
Wang, GY
Stoisavljevic, V
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (09): : 1413 - 1425
[5] Synthesis and pairing properties of oligodeoxynucleotides containing N7-(purin-2-amine deoxynucleosides)
Parel, SP
Leumann, CJ
HELVETICA CHIMICA ACTA, 2000, 83 (09) : 2514 - 2526
[6] OLIGODEOXYNUCLEOTIDES THAT CONTAIN 2',5'' LINKAGES - SYNTHESIS AND HYBRIDIZATION PROPERTIES
DOUGHERTY, JP
RIZZO, CJ
BRESLOW, R
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (15) : 6254 - 6255
[7] Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system
Obika, S
Hari, Y
Morio, K
Imanishi, T
TETRAHEDRON LETTERS, 2000, 41 (02) : 215 - 219
[8] SYNTHESIS AND PROPERTIES OF OLIGODEOXYNUCLEOTIDES CONTAINING THE ANALOG 2'-DEOXY-4'-THIOTHYMIDINE
HANCOX, EL
CONNOLLY, BA
WALKER, RT
NUCLEIC ACIDS RESEARCH, 1993, 21 (15) : 3485 - 3491
[9] Nucleosides and nucleotides.: Part 214:: Thermal stability of triplexes containing 4′α-C-aminoalkyl-2′-deoxynucleosides
Atsumi, N
Ueno, Y
Kanazaki, M
Shuto, S
Matsuda, A
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (09) : 2933 - 2939
[10] NUCLEOSIDES .49. SYNTHESIS AND PROPERTIES OF 2,4-QUINAZOLINEDIONE N-1-2'-DEOXYNUCLEOSIDES, 3'-DEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES
DUNKEL, M
PFLEIDERER, W
NUCLEOSIDES & NUCLEOTIDES, 1992, 11 (2-4): : 787 - 819

← 1 2 3 4 5 →