MATERNAL ALLERGIC AIRWAY INFLAMMATION DURING PREGNANCY ALTERS OFFSPRING'S AIRWAY HYPERRESPONSIVENESS DEPENDENT ON MUSCARINIC RECEPTOR AND ADAM33 MEDIATED MECHANISMS

被引：0
|
作者：
Wandel, M. [1 ]
Davies, E. R. [1 ]
Kelly, J. F. C. [1 ]
Holgate, S. T. [2 ]
Whitsett, J. A. [3 ]
Davies, D. E. [4 ]
Haitchi, H. M. [4 ]
机构：
[1] Univ Southampton, Brooke Labs Clin & Expt Sci, Fac Med, Southampton, Hants, England
[2] Inst Life Sci, Southampton, Hants, England
[3] Cincinnati Childrens Hosp Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA
[4] Univ Hosp Southampton NHS Fdn Trust, Natl Inst Hlth Res NIHR, Southampton Resp Biomed Res Unit, Southampton, Hants, England
来源：
THORAX | 2019年 / 74卷
关键词：
D O I：
10.1136/thorax-2019-BTSabstracts2019.136
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
S130
引用
收藏
页码：A83 / A83
页数：1
相关论文
共 20 条
  • [1] Airway hyperresponsiveness in offspring from mothers with allergic airway inflammation during pregnancy is muscarinic receptor and ADAM33 dependent
    Wandel, Marieke
    Davies, Elizabeth R.
    Kelly, Joanne F. C.
    Holgate, Stephen T.
    Davies, Donna E.
    Haitchi, Hans Michael
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [2] ADAM33 is involved in post-natal airway hyperresponsiveness caused by maternal allergic airway inflammation
    Wandel, Marieke
    Davies, Elizabeth R.
    Kelly, Joanne F. C.
    Holgate, Stephen T.
    Whitsett, Jeffrey A.
    Davies, Donna E.
    Haitchi, Hans Michael
    EUROPEAN RESPIRATORY JOURNAL, 2018, 52
  • [3] SOLUBLE ADAM33 CAUSES AIRWAY REMODELLING TO PROMOTE ALLERGIC AIRWAY INFLAMMATION
    Davies, E. R.
    Whitsett, J. A.
    Davies, D. E.
    Haitchi, H. M.
    THORAX, 2015, 70 : A73 - A73
  • [4] THE EFFECT OF SOLUBLE ADAM33 ON ALLERGIC AIRWAY INFLAMMATION IN EARLY LIFE IS AGE DEPENDENT
    Davies, E. R.
    Wandel, M.
    Kelly, J. F. C.
    Holgate, S. T.
    Whitsett, J. A.
    Davies, D. E.
    Haitchi, H. M.
    THORAX, 2018, 73 : A18 - A18
  • [5] ADAM33 KNOCK-OUT IS PROTECTIVE AGAINST POSTNATAL AIRWAY HYPERRESPONSIVENESS CAUSED BY MATERNAL ALLERGY
    Wandel, M.
    Davies, E. R.
    Kelly, J. F. C.
    Holgate, S. T.
    Whitsett, J. A.
    Davies, D. E.
    Haitchi, H. M.
    THORAX, 2018, 73 : A17 - A18
  • [6] Chronic, Elevated Maternal Corticosterone During Pregnancy in the Mouse Increases Allergic Airway Inflammation in Offspring
    Smith, Arianna L.
    Paul, Emmanuel
    McGee, Devin
    Sinniah, Ranuka
    Flom, Emily
    Jackson-Humbles, Devan
    Harkema, Jack
    Racicot, Karen E.
    FRONTIERS IN IMMUNOLOGY, 2020, 10
  • [7] Soluble ADAM33 augments the pulmonary innate immune response promoting susceptibility to allergic airway inflammation
    Kelly, Joanne
    Davies, Elizabeth
    Xu, Xan
    Whitsett, Jeffery
    Davies, Donna
    Haitchi, Hans Michael
    EUROPEAN RESPIRATORY JOURNAL, 2018, 52
  • [8] Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation
    Straubinger, Kathrin
    Paul, Sabine
    da Costa, Olivia Prazeres
    Ritter, Manuel
    Buch, Thorsten
    Busch, Dirk H.
    Layland, Laura E.
    da Costa, Clarissa U. Prazeres
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (06) : 1271 - +
  • [9] Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children
    Kopriva, Frantisek
    Godava, Marek
    Markova, Marie
    Vodicka, Radek
    Dusek, Ladislav
    Muzik, Jiri
    Schneiderova, Eva
    Vrtel, Radek
    Mihal, Vladimir
    BIOMEDICAL PAPERS-OLOMOUC, 2013, 157 (04): : 367 - 373
  • [10] M3 muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice
    Cao, Rui
    Dong, Xin-Wei
    Jiang, Jun-Xia
    Yan, Xiao-Feng
    He, Jun-Shan
    Deng, Yang-Mei
    Li, Fen-Fen
    Bao, Meng-Ling
    Xie, Yi-Cheng
    Chen, Xiao-Ping
    Xie, Qiang-Min
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 655 (1-3) : 83 - 90
12