Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong

被引：19

作者：

Huang, Jian ^{[1
]}

Lu, Xiao-Qing ^{[1
]}

Lu, Jin ^{[1
]}

Li, Guo-Yu ^{[2
]}

Wang, Hang-Yu ^{[2
]}

Li, Li-Hong ^{[1
]}

Lin, Rui-Chao ^{[3
]}

Wang, Jin-Hui ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China

[3] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2013年 / 15卷 / 12期

关键词：

Ligusticum chuanxiong; chuanxiongdiolide A; chuanxiongdiolide B; NMR; CD; anti-BuChE activity;

D O I：

10.1080/10286020.2013.825610

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new phthalides, chuanxiongdiolides A (1) and B (2), were isolated from the roots of Ligusticum chuanxiong Hort. Their structures were established by UV, IR, 1D (H-1, C-13) and 2D (HSQC, H-1-H-1 COSY, HMBC, NOESY) NMR, and HR-ESI-MS methods, and their absolute configurations were assigned via circular dichroism exciton chirality. The two compounds showed different degrees of inhibitory effects against butyrylcholine esterase.

引用

页码：1237 / 1242

页数：6

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