Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

被引:0
|
作者
Horsch, K
de Wet, H
Langeveldt, C
Hough, S
Burrin, J
Cunningham, J
Schuurmans, M
Hulley, P
机构
[1] Univ Stellenbosch, Fac Hlth Sci, Dept Internal Med, Cape Town, South Africa
[2] St Barts Hosp, London, England
[3] Univ Oxford, Inst Musculoskeletal Sci, Oxford OX1 2JD, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S6 / S6
页数:1
相关论文
共 14 条
  • [1] Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
    Horsch, K
    de Wet, H
    Langeveldt, CR
    Hough, FS
    Burrin, JM
    Cunningham, J
    Hulley, PA
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (06) : 1030 - 1030
  • [2] Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents
    Hulley, PA
    Horsch, K
    De Wet, H
    Conradie, MM
    Langeveldt, C
    Hough, FS
    BONE, 2003, 32 (05) : S137 - S137
  • [3] The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity
    Dorothy Hutter
    Peili Chen
    Janice Barnes
    Yusen Liu
    Molecular and Cellular Biochemistry, 2002, 233 : 107 - 117
  • [4] The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity
    Hutter, D
    Chen, PL
    Barnes, J
    Liu, YS
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 233 (1-2) : 107 - 117
  • [5] Inhibition of NF-κB-dependent Transcription by MKP-1 TRANSCRIPTIONAL REPRESSION BY GLUCOCORTICOIDS OCCURRING VIA p38 MAPK
    King, Elizabeth M.
    Holden, Neil S.
    Gong, Wei
    Rider, Christopher F.
    Newton, Robert
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (39) : 26803 - 26815
  • [6] Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation
    Datta, Nabanita S.
    Kolailat, Rola
    Fite, Alemu
    Pettway, Glenda
    Abou-Samra, Abdul B.
    CELLULAR SIGNALLING, 2010, 22 (03) : 457 - 466
  • [7] Effects of insulin and insulin-like growth factor 1 on osteoblast proliferation and differentiation: differential signalling via Akt and ERK
    Zhang, Wei
    Shen, Xing
    Wan, Chao
    Zhao, Qiang
    Zhang, Lianfang
    Zhou, Qi
    Deng, Lianfu
    CELL BIOCHEMISTRY AND FUNCTION, 2012, 30 (04) : 297 - 302
  • [8] MKP-1 antisense oligonucleotides reverses the LPS-mediated inhibition of angiotensin II-induced cardiac fibroblast proliferation and migration via restoration of MAPK activity
    Stawowy, P
    Blaschke, F
    Kintscher, U
    Goetze, S
    Fleck, E
    Graf, K
    HYPERTENSION, 2002, 40 (03) : 398 - 399
  • [9] Inhibitory effects of Rap1GAP overexpression on proliferation and migration of endothelial cells via ERK and Akt pathways
    Li, Wenyi
    Jin, Bi
    Cornelius, Lynn A.
    Zhou, Bin
    Fu, Xiaoyang
    Shang, Dan
    Zheng, Hong
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2011, 31 (06) : 721 - 727
  • [10] Inhibitory Effects of Rap1GAP Overexpression on Proliferation and Migration of Endothelial Cells via ERK and Akt Pathways
    李文毅
    金毕
    Lynn A.Cornelius
    周斌
    符晓阳
    尚丹
    郑鸿
    Journal of Huazhong University of Science and Technology(Medical Sciences), 2011, 31 (06) : 721 - 727