Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin

被引：14

作者：

Duan, Yanjuan ^{[1
]}

Zou, Jialing ^{[2
]}

Mao, Jingyi ^{[2
]}

Guo, Dongjie ^{[2
]}

Wu, Minfeng ^{[2
]}

Xu, Ning ^{[2
]}

Zhou, Jie ^{[1
]}

Zhang, Yanbin ^{[1
]}

Guo, Wanjun ^{[2
]}

Jin, Waishu ^{[3
]}

机构：

[1] Shanghai Univ TCM, Peoples Hosp 7, Dept Dermatol, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Dermatol, Shanghai, Peoples R China

[3] Qingdao Univ, Yantai Yuhuangding Hosp, Dept Dermatol, 20 Yudong Rd, Yantai 264000, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 115卷

基金：

美国国家科学基金会;

关键词：

Tripterygium wilfordii Hook F; Acitretin; miRNA-126; Plasma; Psoriasis; MICRORNA-126; INFLAMMATION; CYTOKINES; VULGARIS; EFFICACY; MODERATE; SAFETY; INDEX; AREA;

D O I：

10.1016/j.biopha.2019.108761

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Treatment of psoriasis is always difficult, which requires intensive scientific research. Objective: Tripterygium wilfordii Hook F (TwHF) with acitretin(TwHF + acitretin) is normally used in treating psoriasis. This study aimed to investigate the correlation of plasma miR-126 expression with risk and severity of psoriasis, and its predictive value of response to TwHF + acitretin treatment in psoriasis. Methods: MiRNA-126(MiR-126) expression in plasma was analyzed in psoriasis patients at month 0 (M0), M1, M3 and M6 and in health controls (HCs) at enrollment by qPCR. Psoriasis-affected body surface area (BSA) and Psoriasis Area and Severity Index (PASI) score were used to assess severity and treatment response. Results: Plasma miR-126 levels were decreased in psoriasis patients compared with HCs (P < 0.001), with area under the curve (AUC) of 0.771. MiR-126 expression was negatively correlated with PASI score (P = 0.001), and negatively associated with psoriasis-affected BSA (P = 0.825). At M6, 65.3% and 36.1% patients achieved PASI 50 and 75, respectively. MiR-126 increased at M1, M3 and M6 after TwHF + acitretin treatment when comparing with M0 (all P < 0.001). Meanwhile, miR-126 expression baseline in PASI 50 group declined when comparing with non-PASI 50 group (P < 0.001). Additionally, data revealed that the cause of high miR-126 baseline level was due to unsuccessfully achieving PASI 50 at M6 after TwHF + acitretin treatment (P < 0.001). However, miR-126 baseline expression was not a predictive factor for PASI 75 achievement (P > 0.05). Conclusion: Plasma miR-126 expression is negatively correlated with psoriasis risk and severity, and its high baseline level can be used as a biomarker to predict worse clinical response to TwHF + acitretin treatment in psoriasis.

引用

页数：7