Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis

被引：73
|
作者：
Singer, Oded [1 ]
Verma, Inder M. [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
CURRENT GENE THERAPY | 2008年 / 8卷 / 06期
关键词：
D O I：
10.2174/156652308786848067
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.
引用
收藏
页码：483 / 488
页数：6
相关论文
共 50 条
  • [1] Lentiviral vectors mediated transgenesis
    Verp, Sonia
    Blom, Michelle
    Friedli, Marc
    Delpretti, Saskia
    Barde, Isabelle
    Duboule, Denis
    Warot, Xavier
    Trono, Didier
    [J]. TRANSGENIC RESEARCH, 2011, 20 (05) : 1170 - 1170
  • [2] Lentiviral vectors: are they the future of animal transgenesis?
    Park, Frank
    [J]. PHYSIOLOGICAL GENOMICS, 2007, 31 (02) : 159 - 173
  • [3] Transgenesis in the rabbit using lentiviral vectors
    Hoffmann, Orsolya Ivett
    Hiripi, L.
    Negre, D.
    Cosset, F-L
    Kvell, K.
    Czoempoely, T.
    Baranyi, M.
    Gocza, E.
    Bender, B.
    Bosze, Zs
    [J]. TRANSGENIC RESEARCH, 2010, 19 (02) : 333 - 333
  • [4] Applications of lentiviral transgenesis in the chick
    Song, Feifei
    Sherman, A.
    Worthington, I.
    McGrew, M. J.
    Lillico, S. G.
    Sang, H. M.
    [J]. TRANSGENIC RESEARCH, 2010, 19 (02) : 350 - 350
  • [5] Applications of lentiviral transgenesis in the chick
    Song, Feifei
    Sherman, Adrian
    Worthington, Isabelle
    McGrew, Mike
    Sang, Helen
    [J]. MECHANISMS OF DEVELOPMENT, 2009, 126 : S143 - S143
  • [6] Tissue-specific transgenesis by lentiviral vectors
    Tanaka, N
    Ikawa, M
    Kao, WWY
    Verma, IM
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U87 - U87
  • [7] Efficient transgenesis in farm animals by lentiviral vectors
    Hofmann, A
    Kessler, B
    Ewerling, S
    Weppert, M
    Vogg, B
    Ludwig, H
    Stojkovic, M
    Boelhauve, M
    Brem, G
    Wolf, E
    Pfeifer, A
    [J]. EMBO REPORTS, 2003, 4 (11) : 1054 - 1060
  • [8] Lentiviral delivery of shRNA in glioblastoma multiforme spheroids
    Bleeker, F. E.
    De Witt Hamer, P. C.
    van Tilborg, A. A. G.
    Vandertop, W. P.
    van Noorden, C. J. F.
    Leenstra, S.
    [J]. NEURO-ONCOLOGY, 2006, 8 (04) : 329 - 329
  • [9] Lentiviral transgenesis
    Alexander Pfeifer
    [J]. Transgenic Research, 2004, 13 : 513 - 522
  • [10] Lentiviral transgenesis
    Pfeifer, A
    [J]. TRANSGENIC RESEARCH, 2004, 13 (06) : 513 - 522
12345