Patterns of care and survival outcomes for laryngeal small cell cancer

被引：2
|
作者：
Lin, Alexander J. [1 ]
Gabani, Prashant [1 ]
Fischer-Valuck, Ben [1 ]
Rudra, Soumon [1 ]
Gay, Hiram [1 ]
Daly, Mackenzie [1 ]
Oppelt, Peter [2 ]
Jackson, Ryan [3 ]
Rich, Jason [3 ]
Paniello, Randal [3 ]
Zevallos, Jose [3 ]
Adkins, Douglas [2 ]
Thorstad, Wade [1 ]
机构：
[1] Washington Univ, Dept Radiat Oncol, Sch Med, 4921 Parkview Pl,Campus Box 8224, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, Div Hematol & Oncol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Otolaryngol, Div Head & Neck Oncol Surg, St Louis, MO 63110 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 03期
关键词：
chemotherapy; head and neck; neuroendocrine cancer; radiation; surgery; NEUROENDOCRINE CARCINOMA; LUNG-CANCER; THORACIC RADIOTHERAPY; NEOPLASMS; PHASE-3;
D O I：
10.1002/hed.25430
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression. Results From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P = .001), and definitive radiation was less likely given in metastatic disease (P < .001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P = .04). In multivariable modeling, radiation dose >= 40 Gy was associated with better OS (P < .001). Conclusion Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose >= 40 Gy was associated with improved OS.
引用
收藏
页码：722 / 729
页数：8
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