Atopy patch tests are useful to predict oral tolerance in children with gastrointestinal symptoms related to non-IgE-mediated cow's milk allergy

被引：22
|
作者：
Nocerino, R.
Granata, V.
Di Costanzo, M.
Pezzella, V.
Leone, L.
Passariello, A. [2 ]
Terrin, G. [3 ]
Troncone, R. [1 ]
Canani, R. Berni [1 ]
机构：
[1] Univ Naples Federico II, European Lab Invest Food Induced Dis ELFID, Dept Pediat, I-80131 Naples, Italy
[2] Monaldi Hosp, Pediat Unit, Naples, Italy
[3] Univ Roma La Sapienza, Dept Gynecol Obstet & Perinatal Med, Rome, Italy
来源：
ALLERGY | 2013年 / 68卷 / 02期
关键词：
cow's milk protein; food allergy; oral food challenge; oral tolerance; pediatric patients; FOOD ALLERGY; DIAGNOSIS;
D O I：
10.1111/all.12071
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopy patch tests (APTs) have been proposed for the diagnostic approach in children with non-IgE-mediated cow's milk allergy and gastrointestinal symptoms. We aimed to investigate the benefit of APTs in predicting oral tolerance in these patients. We prospectively evaluated 172 subjects with a sure diagnosis of non-IgE-mediated CMA and gastrointestinal symptoms (97 boys, 56.4%; age, 6.37 m; range, 212 m). At diagnosis, 113/172 (65.7%) children had positive APTs to cow's milk proteins (CMP). After 12 months of exclusion, diet APTs were repeated immediately before OFC. APTs significantly correlated (P < 0.001) with the OFC outcome (r 0.579). Diagnostic accuracy was sensitivity of 67.95%, specificity of 88.3%, PPV of 82.81%, NPV of 76.85%, and a +LR of 5.80. APTs are a valuable tool in the follow-up of children with non-IgE-mediated CMA-related gastrointestinal symptoms by contributing in determining whether an OFC can safely be undertaken.
引用
收藏
页码：246 / 248
页数：3
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