An efficient one-pot protocol for regioselective synthesis of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c] pyridazine-5(6H)-ones

被引：10

作者：

Khalafy, Jabbar ^{[1
]}

Rimaz, Mehdi ^{[2
]}

Rabiei, Hossein ^{[1
]}

Panahi, Leila ^{[1
]}

机构：

[1] Urmia Univ, Dept Chem, Orumiyeh, Iran

[2] Payame Noor Univ, Dept Chem, Tehran, Iran

来源：

JOURNAL OF SULFUR CHEMISTRY | 2013年 / 34卷 / 04期

关键词：

pyrimido[4; 5-c]pyridazines; regioselective; one-pot; arylglyoxal; thiobarbituric acid; 3 COMPONENT SYNTHESIS; MONOAMINE-OXIDASE; MULTICOMPONENT REACTIONS; PYRIDAZINE DERIVATIVES; 3-COMPONENT SYNTHESIS; ORGANIC-SYNTHESIS; DOMINO REACTIONS; SULFUR ANALOGS; INHIBITORS; ACID;

D O I：

10.1080/17415993.2012.745126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazine-5(6H)-one derivatives have been regioselectively synthesized via the one-pot three-component reaction of 1,3-dimethylthiobarbituric acid and 1,3-diethylthiobarbituric acid with various arylglyoxals in the presence of hydrazinium dihydrochloride in warm ethanol. These new substituted pyrimidopyridazines may be potential monoamine oxidase inhibitors. [GRAPHICS] .

引用

页码：395 / 406

页数：12

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