A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress

被引：32

作者：

Huang, Chao ^{[1
,3
]}

Yao, Ruyu ^{[2
,9
,10
]}

Zhu, Zhongkai ^{[2
,3
]}

Pang, Dejiang ^{[4
,5
]}

Cao, Xiyue ^{[1
,3
]}

Feng, Bin ^{[6
]}

Paulsen, Berk Smestad ^{[7
]}

Li, Lixia ^{[2
]}

Yin, Zhongqiong ^{[2
,3
]}

Chen, Xingfu ^{[8
]}

Jia, Renrong ^{[3
]}

Song, Xu ^{[2
,3
]}

Ye, Gang ^{[2
]}

Luo, Qihui ^{[1
,3
]}

Chen, Zhengli ^{[1
,3
]}

Zou, Yuanfeng ^{[2
,3
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Lab Expt Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Sichuan, Peoples R China

[3] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Neurosci & Metab Res, Chengdu 610041, Sichuan, Peoples R China

[5] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China

[7] Univ Oslo, Sch Pharm, POB 1068, N-0316 Oslo, Norway

[8] Sichuan Agr Univ, Coll Agron, Minist Agr, Key Lab Crop Ecophysiol & Farming Syst Southwest, Chengdu 611130, Sichuan, Peoples R China

[9] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[10] Peking Union Med Coll, Beijing 100193, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 130卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Lycium barbarum; Pectic polysaccharide; ER stress; STRUCTURAL-CHARACTERIZATION; ER STRESS; ASTRAGALUS POLYSACCHARIDES; HYPOGLYCEMIC ACTIVITY; RAT MODEL; ACID; PURIFICATION; INFLAMMATION; HOMEOSTASIS; EXPRESSION;

D O I：

10.1016/j.ijbiomac.2019.02.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutral polysaccharides from Ningxia L. barbarum fruit have been reported with immunomodulatory and antioxidative biological activities. Few studies on pectic polysaccharides have been reported, especially not from the Xinjiang L. barbarum. In the present study, a pectic polysaccharide, XLBP-I-I, was obtained from water decoction of Xinjiang L barbarum using anion exchange chromatography and gel filtration. The results from methanolysis, methylation, FT-IR and NMR experiments indicated that XLBP-I-I was a typical pectic polysaccharide. In vitro assay showed that XLBP-I-I could reduce the ER stress and UPR in tunicamycin insult IPEC-J2 cells, and further protect IPEC-J2 cells against apoptosis induced by ER stress. These results reveal a new perspective for pectic L barbarum polysaccharides on intestine ER stress, and this elicited interests for its further applications. (C) 2019 Published by Elsevier B.V.

引用

页码：508 / 514

页数：7

共 21 条

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