Human anti-interleukin IL-12/IL-23 p40 mAb (CNTO1275) inhibits IL-12-induced expression of skin homing molecule, cutaneous lymphocyte antigen and IL-12 receptors on activated peripheral blood T lymphocytes

被引：0
|
作者：
Reddy, MP [1 ]
Davis, C [1 ]
Wong, J [1 ]
Pendley, C [1 ]
Prabhakar, U [1 ]
机构：
[1] Centocor Inc, Radnor, PA USA
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2006年 / 154卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页数：1
相关论文
共 36 条
  • [1] Anti IL-12/IL-23 p40 therapy inhibits epidermal activation in uninvolved psoriatic skin
    Baerveldt, Ewout
    Onderdijk, Armanda
    Kant, Marius
    Florencia, Eddy
    Gudjonsson, Johann
    Thio, Bing
    Laman, Jon
    Prens, Errol
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 : S44 - S44
  • [2] Administration of anti-IL-12 mAb in Crohn's disease patients leads to downmodulation of p40 expression and IL-12/IL-23 derived cytokines
    Fuss, IJ
    Becker, C
    Yang, ZQ
    Groden, C
    Hornung, R
    Nikolaev, A
    Heller, F
    Neurath, M
    Strober, W
    Mannon, PJ
    GASTROENTEROLOGY, 2005, 128 (04) : A118 - A118
  • [3] Expression of interleukin (IL)-12 (p40) and IL-12 (β2) receptors in allergic rhinitis and chronic sinusitis
    Wright, ED
    Christodoulopoulos, P
    Frenkiel, S
    Hamid, Q
    CLINICAL AND EXPERIMENTAL ALLERGY, 1999, 29 (10): : 1320 - 1325
  • [4] Human IL-12/23 mAb inhibits cutaneous lymphocyte antigen, IL-12R, and IL-2Rα expression on activated peripheral blood T lymphocytes and secretion of IFN-γ, IL-17, IL-2, IL-10, and TNF-α cytokines
    Reddy, M.
    Davis, C.
    Wong, J.
    Fried, N.
    Pendley, C.
    Prabhakar, U.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 : 114 - 114
  • [5] Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis
    Jana, Malabendu
    Mondal, Susanta
    Jana, Arundhati
    Pahan, Kalipada
    CYTOKINE, 2024, 174
  • [6] ASSOCIATION BETWEEN DISEASE ACTIVITY AND IL-17A/F, IL-23 AND IL-12/23 (p40) PRODUCTION BY PERIPHERAL BLOOD T LYMPHOCYTES IN BEHCET'S DISEASE
    Yucel, Aysegul Atak
    Sonmez, Cemile
    Yesii, Turan Hilmi
    Kucuk, Hamit
    Mercan, Ridvan
    Yucel, Eftal Ahmet
    Goker, Berna
    Tufan, Muge Aydin
    Demirel, Gulderen Yanikkaya
    Sezgin, Berna
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [7] Drug evaluation: CNTO-1275, a mAb against IL-12/IL-23p40 for the potential treatment of inflammatory diseases
    Wittig, Bianca Maria
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2007, 8 (11) : 947 - 954
  • [8] Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet’s patients
    Cemile Sonmez
    Aysegul Atak Yucel
    Turan Hilmi Yesil
    Hamit Kucuk
    Berna Sezgin
    Ridvan Mercan
    Ahmet Eftal Yucel
    Gulderen Yanikkaya Demirel
    Clinical Rheumatology, 2018, 37 : 2797 - 2804
  • [9] Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet's patients
    Sonmez, Cemile
    Yucel, Aysegul Atak
    Yesil, Turan Hilmi
    Kucuk, Hamit
    Sezgin, Berna
    Mercan, Ridvan
    Yucel, Ahmet Eftal
    Demirel, Gulderen Yanikkaya
    CLINICAL RHEUMATOLOGY, 2018, 37 (10) : 2797 - 2804
  • [10] Induction of IL-12/IL-23 by Substance P in human PBMC and expression of Substance P receptor in peripheral blood of MS patients
    Kawabe, Kiyokazu
    Braitch, Manjit
    Vilisaar, Janek
    Constantinescu, Cris S.
    JOURNAL OF NEUROIMMUNOLOGY, 2008, 203 (02) : 135 - 136
1234