Natural history of atopic dermatitis: Studies of neonatal cohorts

被引：2
|
作者：
Just, J. [1 ]
机构：
[1] Univ Paris 06, Ctr Asthme & Allergies, Hop Enfants Armand Trousseau, Grp Hosp Trousseau La Roche Guyon, F-75571 Paris 12, France
来源：
REVUE FRANCAISE D ALLERGOLOGIE | 2012年 / 52卷 / 03期
关键词：
Atopic dermatitis; Filaggrin; Immunity; Atopic march; SKIN BARRIER FUNCTION; MAST-CELL CHYMASE; BIRTH COHORT; ALLERGIC SENSITIZATION; EPIDERMAL BARRIER; HAY-FEVER; FILAGGRIN MUTATIONS; RISK-FACTORS; ECZEMA; ASTHMA;
D O I：
10.1016/j.reval.2012.01.008
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis, a heterogeneous disease characterized by chronic inflammation of the skin, affects 15 to 30% of children. Studies of neonatal cohorts have contributed significant advances to our understanding of atopic dermatitis, allowing us to discover genetic and environmental factors, which favor its development. Currently, two distinct groups of genes are implicated in atopic dermatitis, in particular, genes involved in the integrity of the cutaneous barrier and genes involved in innate and adaptive immunity. Precocious sensitivity through the skin could be the first step in the atopic march, being responsible for food allergy associated with atopic dermatitis in young infants, which then progresses to allergic rhinitis and asthma in childhood and into adolescence. (C) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：168 / 174
页数：7
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