Anti-proliferative Neolignans from Saururus chinensis against Human Cancer Cell Lines

被引：20

作者：

Lee, You Jin ^{[1
]}

Kim, Jinhee ^{[1
]}

Yi, Jin-Mu ^{[1
]}

Oh, Se-Mi ^{[1
]}

Kim, No Soo ^{[1
]}

Kim, Haejin ^{[1
]}

Oh, Dal-Seok ^{[1
]}

Bang, Ok-Sun ^{[1
]}

Lee, Jun ^{[1
]}

机构：

[1] Korea Inst Oriental Med, Herbal Med Res Div, TKM Based Herbal Drug Res Grp, Taejon 305811, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2012年 / 35卷 / 08期

关键词：

Saururus chinensis; neolignan; anti-proliferation; anti-cancer; medicinal herb; NF-KAPPA-B; MANASSANTIN-A; FLAVONOL GLYCOSIDES; AERIAL PARTS; NITRIC-OXIDE; TNF-ALPHA; CONSTITUENTS; EXPRESSION; INHIBITION; EXTRACT;

D O I：

10.1248/bpb.b110670

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activity-guided fractionation of an 80% EtOH extract from the aerial parts of Saururus chinensis led to isolation of three anti-proliferative neolignans (1-3) along with four flavonoids (4-7) and four aristolactams (8-11). Their chemical structures were identified by analysis of spectroscopic data. All compounds 1-11 were evaluated for their activities against 28 human cancer cell lines using an in vitro cell proliferation assay. Compounds 1-3 showed potent anti-proliferative activities against cervical (C33a, IC50=0.01 mu M for 1; 0.28 mu M for 2; 2.80 mu M for 3) and lung (NCI-H460, IC50=0.05 mu M for 1; 1.37 mu M for 2; 6.46 mu M for 3) cancer cells without any remarkable cytotoxic effects on human normal lung cells as a control. Taken together, these data demonstrated the identification of anti-proliferative neolignans which are active components of S. chinensis.

引用

页码：1361 / 1366

页数：6

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