CLINICAL AND PHARMACODYNAMIC BIOMARKER RESULTS FROM PORTER, A MULTI-COHORT PHASE 1 PLATFORM TRIAL OF COMBINATION IMMUNOTHERAPY FOR METASTATIC CASTRATION-RESISTANT PROSTATE CANCER PATIENTS

被引:0
|
作者
Galsky, Matthew [1 ]
Autio, Karen [2 ]
Wentzel, Kristopher [3 ]
Graff, Julie [4 ]
Friedlander, Terence [5 ]
Densmore, Julie [6 ]
Cabanski, Christopher [6 ]
Shotts, Kristin [6 ]
Howes, Tim [6 ]
Yu, Jia [6 ]
Eisenbeisz, Elaine [6 ]
Spasic, Marko [6 ]
Maddock, Stephen [6 ]
DaSilva, Diane [6 ]
Kumar, Dinesh [6 ]
Moore, Jonni [7 ]
Schretzenmair, Richard [8 ]
Lata, Jennifer [8 ]
Xu, Arron [8 ]
Reuschel, Emma [8 ]
Wani, Snehal [8 ]
Morrow, Matthew [8 ]
Skolnik, Jeffrey [8 ]
Santulli-Marotto, Sandra [6 ]
Padron, Lacey [6 ]
Butterfield, Lisa [6 ]
LaVallee, Theresa [6 ]
Bucktrout, Samantha [6 ]
Yellin, Michael [9 ]
Keler, Tibor [9 ]
Salvador, Lisa [10 ]
O'Donnell-Tormey, Jill [11 ]
Lucey, Vanessa [11 ]
Fairchild, Justin [6 ]
Dugan, Ute [6 ]
Bhardwaj, Nina [1 ]
Subudhi, Sumit [12 ]
Fong, Lawrence [5 ]
机构
[1] Mt Sinai Med Ctr, New York, NY 10029 USA
[2] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[3] Angeles Clin, Los Angeles, CA USA
[4] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
[5] Univ Calif San Francisco, San Francisco, CA 94143 USA
[6] Parker Inst Canc Immunotherapy, San Francisco, CA USA
[7] Univ Penn, Philadelphia, PA 19104 USA
[8] Inovio Pharmaceut, Plymouth Meeting, PA USA
[9] Celldex Therapeut, Hampton, NJ USA
[10] Bristol Myers Squibb, Princeton, NJ USA
[11] Canc Res Inst, New York, NY USA
[12] MD Anderson, Houston, TX USA
关键词
D O I
10.1136/jitc-2022-SITC2022.0555
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
555
引用
收藏
页码:A580 / A580
页数:1
相关论文
共 50 条
  • [1] BIOMARKER CORRELATES OF CLINICAL RESPONSE WITH FLT3L/NIVO BACKBONE TREATMENT IN THE MULTI-COHORT PHASE 1 PORTER PLATFORM TRIAL IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER PATIENTS
    Shotts, Kristin
    Howes, Timothy
    Yu, Jia
    Densmore, Julie
    Da Silva, Diane
    Kumar, Dinesh
    Santulli-Marotto, Sandra
    Cabanski, Christopher
    Eisenbeisz, Elaine
    Ivison, Geoffrey
    Mayer, Aaron
    Moore, Jonni
    Jones, Derek
    Kraynyak, Kimberly
    Dolgoter, Alex
    Chen, Richard
    Butterfield, Lisa
    LaVallee, Theresa
    Bucktrout, Samantha
    Padron, Lacey
    Dugan, Ute
    Yellin, Michael
    Keler, Tibor
    O'Donnell-Tormey, Jill
    Fairchild, Justin
    Salvador, Lisa
    Wentzel, Kristopher
    Fong, Lawrence
    Subudhi, Sumit
    Bhardwaj, Nina
    Autio, Karen
    Galsky, Matthew
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A585 - A585
  • [2] Phase II clinical trial of cediranib in patients with metastatic castration-resistant prostate cancer
    Dahut, William L.
    Madan, Ravi A.
    Karakunnel, Joyson J.
    Adelberg, David
    Gulley, James L.
    Turkbey, Ismail B.
    Chau, Cindy H.
    Spencer, Shawn D.
    Mulquin, Marcia
    Wright, John
    Parnes, Howard L.
    Steinberg, Seth M.
    Choyke, Peter L.
    Figg, William D.
    BJU INTERNATIONAL, 2013, 111 (08) : 1269 - 1280
  • [3] Biomarker Development Trial of Satraplatin in Patients with Metastatic Castration-Resistant Prostate Cancer
    Liaw, Bobby C.
    Tsao, Che-Kai
    Seng, Sonia
    Jun, Tomi
    Gong, Yixuan
    Galsky, Matthew D.
    Oh, William K.
    ONCOLOGIST, 2022, : 366 - 367+e218
  • [4] Phase 1 efficacy and pharmacodynamic results of exicorilant plus enzalutamide in patients with metastatic castration-resistant prostate cancer.
    Morris, Michael J.
    Linch, Mark David
    Crabb, Simon J.
    Beer, Tomasz M.
    Heath, Elisabeth I.
    Gordon, Michael S.
    De Bono, Johann S.
    Pashova, Hristina I.
    Tudor, Iulia Cristina
    Greenstein, Andrew E.
    Mann, Grace
    Liu, Glenn
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41
  • [5] Sunitinib in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic, castration-resistant prostate cancer: a phase 1/2 clinical trial
    Zurita, A. J.
    George, D. J.
    Shore, N. D.
    Liu, G.
    Wilding, G.
    Hutson, T. E.
    Kozloff, M.
    Mathew, P.
    Harmon, C. S.
    Wang, S. L.
    Chen, I.
    Maneval, E. Chow
    Logothetis, C. J.
    ANNALS OF ONCOLOGY, 2012, 23 (03) : 688 - 694
  • [6] Phase I trial with a combination of docetaxel and 153Sm-lexidronam in patients with castration-resistant metastatic prostate cancer
    Lin, Jianqing
    Sinibaldi, Victoria J.
    Carducci, Michael A.
    Denmeade, Samuel
    Song, Danny
    DeWeese, Theodore
    Eisenberger, Mario A.
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2011, 29 (06) : 670 - 675
  • [7] Translation of Prognostic and Pharmacodynamic Biomarkers from Trial to Non-trial Patients with Metastatic Castration-resistant Prostate Cancer Treated with Docetaxel
    Elumalai, T.
    Barker, C.
    Elliott, T.
    Malik, J.
    Tran, A.
    Hudson, A.
    Song, Y. P.
    Patel, K.
    Lyons, J.
    Hoskin, P.
    Choudhury, A.
    Mistry, H.
    CLINICAL ONCOLOGY, 2022, 34 (07) : E291 - E297
  • [8] A multicenter, open-label, exploratory platform study to evaluate biomarkers and immunotherapy combinations for the treatment of patients with metastatic castration-resistant prostate cancer (PORTER)
    Nissola, Leo
    Autio, Karen
    Bhardwaj, Nina
    Galsky, Matthew
    Wentzel, Kristopher
    Lucey, Vanessa
    Selinsky, Cheryl
    Perry, Christopher
    Cabanski, Christopher
    Bitton, Ari
    Fairchild, Justin
    Horak, Christine
    Skolnik, Jeffrey
    Yellin, Michael
    Dugan, Ute
    Ibrahim, Ramy
    Fong, Lawrence
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [9] A Phase II Trial of Temsirolimus in Men With Castration-Resistant Metastatic Prostate Cancer
    Armstrong, Andrew J.
    Shen, Tong
    Halabi, Susan
    Kemeny, Gabor
    Bitting, Rhonda L.
    Kartcheske, Patricia
    Embree, Elizabeth
    Morris, Karla
    Winters, Carolyn
    Jaffe, Tracy
    Fleming, Mark
    George, Daniel J.
    CLINICAL GENITOURINARY CANCER, 2013, 11 (04) : 397 - 406
  • [10] A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer
    Armstrong, Andrew J.
    Shen, Tong
    Halabi, Susan
    Kemeny, Gabor
    Bitting, Rhonda Lynn
    Kartcheske, Patricia
    Embree, Elizabeth
    Morris, Karla
    Winters, Carolyn
    Jaffe, Tracy
    Fleming, Mark T.
    George, Daniel J.
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (06)