Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts

被引：0
|
作者：
Subramani, Tamilselvan [1 ,2 ]
Rao, Suresh [2 ]
Senthilkumar, Kamatchiammal [3 ]
Periasamy, Soundararajan [4 ]
Alitheen, Noorjahan Banu [1 ]
机构：
[1] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Cell & Mol Biol, Serdang 43400, Malaysia
[2] Sri Ramachandra Univ, Fac Dent Sci, Dept Periodont, Madras, Tamil Nadu, India
[3] Natl Environm Engn Res Inst, Div Virol, Madras, Tamil Nadu, India
[4] Sri Ramachandra Univ, Fac Med, Dept Nephrol, Madras, Tamil Nadu, India
来源：
BIOCELL | 2013年 / 37卷 / 03期
关键词：
angiotensin; c-Jun; c-Fos; transcription factor; cyclosporine; gingival overgrowth;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibfibroblast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibfibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibfibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibfibroblast cells.
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页码：71 / 76
页数：6
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