The pathogenesis of Nipah virus: A review

被引：17
|
作者：
Devnath, Popy [1 ]
Wajed, Shah [1 ]
Das, Ripu Chandra [1 ]
Kar, Sanchita [2 ]
Islam, Iftekharul [1 ]
Al Masud, H. M. Abdullah [3 ]
机构：
[1] Noakhali Sci & Technol Univ, Dept Microbiol, Noakhali 3814, Bangladesh
[2] Child Hlth Res Fdn, Dhaka 1207, Bangladesh
[3] Univ Chittagong, Fac Biol Sci, Dept Microbiol, Chattogram 4331, Bangladesh
来源：
MICROBIAL PATHOGENESIS | 2022年 / 170卷
关键词：
Nipah virus; Pathogenesis; Emerging virus; Zoonosis; Antiviral drug; HENDRA VIRUS; V-PROTEIN; HENIPAVIRUS INFECTION; NUCLEOCAPSID PROTEIN; W-PROTEIN; ATTACHMENT GLYCOPROTEIN; PARAMYXOVIRUS FUSION; CRYSTAL-STRUCTURE; RNA HELICASE; PIG-FARMERS;
D O I：
10.1016/j.micpath.2022.105693
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nipah virus (NiV), an emerging zoonotic virus, has been associated with several outbreaks with high death rates, mainly in South and Southeast Asia. NiV is responsible for Encephalitis and systemic vasculitis, and occasionally respiratory diseases accompanied by it. Though fruit bats are the natural source of NiV, it can be transmitted in a zoonotic manner directly or via an intermediate host (e.g., a pig or horse). Several studies explore the viral mechanism of disease progressions and its overall pathogenesis. However, understanding the pathogenesis and disease dynamics is necessary to develop therapeutic options and vaccines. Thus, in this review, we provide a comprehensive update on the emerging understanding of the pathogenesis of NiV.
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页数：11
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