The aging-disease false dichotomy: understanding senescence as pathology

被引：46
|
作者：
Gems, David [1 ,2 ]
机构：
[1] UCL, Inst Healthy Aging, London WC1E 6BT, England
[2] UCL, Dept Genet, London WC1E 6BT, England
来源：
FRONTIERS IN GENETICS | 2015年 / 6卷
基金：
英国惠康基金;
关键词：
CAENORHABDITIS-ELEGANS; ACCUMULATION; STRESS;
D O I：
10.3389/fgene.2015.00212
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
From a biological perspective aging (senescence) appears to be a form of complex disease syndrome, though this is not the traditional view. This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new. The conceptual division between aging-related diseases and an underlying, non-pathological aging process underpins various erroneous traditional ideas about aging. Among biogerontologists, another likely error involves the aspiration to treat the entire aging process, which recent advances suggest is somewhat utopian. It also risks neglecting a more modest but realizable goal: to develop preventative treatments that partially protect against aging.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] The aging-disease dichotomy: True or false?
    Blumenthal, HT
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2003, 58 (02): : 138 - 145
  • [2] THE AGING-DISEASE DICHOTOMY IS ALIVE, BUT IS IT WELL
    BLUMENTHAL, HT
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1993, 41 (11) : 1272 - 1273
  • [3] BRIDGING THE AGING-DISEASE DICHOTOMY .1. THE AMYLOIDOSIS MODEL
    BLUMENTHAL, HT
    PREMACHANDRA, BN
    [J]. PERSPECTIVES IN BIOLOGY AND MEDICINE, 1990, 33 (03) : 402 - 420
  • [4] THE AGING-DISEASE DICHOTOMY - CEREBRAL AMYLOID ANGIOPATHY - AN INDEPENDENT ENTITY ASSOCIATED WITH DEMENTIA
    BLUMENTHAL, HT
    PREMACHANDRA, BN
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1990, 38 (04) : 475 - 482
  • [5] Aging-disease relationship in Japan
    Ooe, Y
    Furukawa, T
    [J]. GERONTOLOGIST, 2002, 42 : 46 - 46
  • [6] SENESCENCE AND PATHOLOGY IN AGING
    MERA, SL
    [J]. MEDICAL LABORATORY SCIENCES, 1992, 49 (04): : 271 - 282
  • [7] Endothelial cell senescence-understanding aging and disease
    Coleman, Paul R.
    Ting, Ka K.
    Qi, Yanfei
    Vadas, Mathew A.
    Gamble, Jennifer R.
    [J]. CURRENT OPINION IN PHYSIOLOGY, 2023, 35
  • [8] A view of the aging-disease relationship from age 85
    Blumenthal, HT
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (06): : B255 - B259
  • [9] Cellular Senescence in Tendon Aging and Pathology
    Gingery, Anne
    Tchkonia, Tamara
    Kirkland, James C.
    Amadio, Peter C.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2018, 33 : 10 - 10
  • [10] AGING KIDNEY: SENESCENCE OR DISEASE?
    Gursu, Meltem
    Kazancioglu, Rumeyza
    Ozturk, Savas
    [J]. NOBEL MEDICUS, 2013, 9 (02): : 10 - 14
12345