Developments in virus-like particle-based vaccines for HIV

被引：1

作者：

Buonaguro, Luigi ^{[1
]}

Tagliamonte, Maria ^{[1
]}

Visciano, Maria Luisa ^{[1
]}

Tornesello, Maria Lina ^{[1
]}

Buonaguro, Franco M. ^{[1
]}

机构：

[1] Ist Nazl Tumori Fond Pascale, Dept Expt Oncol, Mol Biol & Viral Oncol Unit, I-80131 Naples, Italy

来源：

EXPERT REVIEW OF VACCINES | 2013年 / 12卷 / 02期

关键词：

baculovirus expression vector system; broadly neutralizing antibody; conformational antigen presentation; HIV-VLPs; insect cells stable expression; vaccines; T-CELL RESPONSES; ANTIGEN-PRESENTING CELLS; ACTIVATE DENDRITIC CELLS; BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION PROFILE; TOLL-LIKE RECEPTORS; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSES; CLASS-I; ENVELOPE GLYCOPROTEINS;

D O I：

10.1586/ERV.12.152

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4(+) T-helper and CD8(+) cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

引用

页码：119 / 127

页数：9

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