The role of biology in the diagnosis of cerebrospinal fluid leaks

被引：2

作者：

Tabaouti, K. ^{[1
]}

Kraoul, L. ^{[1
]}

Alyousef, L. ^{[1
]}

Lahoud, G. Abi ^{[2
]}

Rousset, S. Brovedani ^{[1
]}

Lancelin, F. ^{[1
]}

Mouchet, E. ^{[1
]}

Piketty, M. -L. ^{[1
]}

机构：

[1] Ctr Hosp St Anne, Biol Lab, Paris, France

[2] Ctr Hosp St Anne, Serv Neurochirurg, Paris, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2009年 / 67卷 / 02期

关键词：

cerebrospinal fluid; CSF leakage; beta-trace protein; beta; 2-transferrin; BETA-TRACE-PROTEIN; PROSTAGLANDIN-D SYNTHASE; CARBOHYDRATE-DEFICIENT TRANSFERRIN; GEL-ELECTROPHORESIS; RELIABLE DIAGNOSIS; CSF LEAKAGE; MARKER; RHINORRHEA; IDENTIFICATION; MANAGEMENT;

D O I：

10.1684/abc.2008.0294

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Cerebrospinal fluid leakage is a rare but critical condition with a substantial risk of intracranial infection, therefore its diagnosis and treatment is of major importance. CSF leakage diagnostic can be a challenging problem. Nephelometric measurement of beta-trace protein in the liquorrhoea is a noninvasive and fast method that can be used for CSF leakage diagnosis. It should kept in mind, however, that the cut-off of 1.1 mg/L is not suitable for patients with bacterial meningitis and those with a reduced glomerular filtration rate. Complementary use of beta-trace protein assay and beta 2-transferrin detection is therefore recommended.

引用

页码：141 / 151

页数：11

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