Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents

被引：0

作者：

Mustahil, Noorul Adawiyah ^{[1
]}

Sukari, Mohd Aspollah ^{[1
]}

Abdul, Ahmad Bustamam ^{[2
]}

Ali, Nor Azah ^{[3
]}

Lian, Gwendoline Ee Cheng ^{[1
]}

机构：

[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang, Selangor, Malaysia

[2] UPM Serdang, Inst Biosci, UPM MAKNA Canc Res Lab, Selangor Darul Ehsan, Malaysia

[3] FRIM, Kepong, Malaysia

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2013年 / 26卷 / 02期

关键词：

Alpinia mutica; CEMss; flavokawin B; antimicrobial; DPPH; PIPER-METHYSTICUM; CANCER CELLS; ANTIOXIDANT; RHIZOMES; CYTOTOXICITY; FLAVONOIDS; PROPOLIS; EXTRACTS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with beta-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 mu g/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86 +/- 0.37 mu g/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.

引用

页码：391 / 395

页数：5

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