Detection of Chlamydophila pneumoniae DNA in peripheral blood mononuclear cells of blood donors in the north-east of Italy

被引：14
|
作者：
Rassu, M
Lauro, FM
Cazzavillan, S
Bonoldi, E
Belloni, M
Bettini, MC
Pilotto, A
Mengoli, C
Peron, A
Zambello, R
Scagnelli, M
Bertoloni, G
机构：
[1] San Bortolo Hosp, Dept Microbiol, I-36100 Vicenza, Italy
[2] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy
[3] San Bortolo Hosp, Dept Pathol, I-36100 Vicenza, Italy
[4] San Bortolo Hosp, Transfus Unit, I-36100 Vicenza, Italy
[5] San Bortolo Hosp, Dept Geriatr, I-36100 Vicenza, Italy
[6] Univ Padua, Dept Clin & Expt Med, Clin Immunol Branch, I-35121 Padua, Italy
来源：
MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2001年 / 190卷 / 03期
关键词：
Chlamydophila pneumoniae; polymerase chain reaction; blood donors; peripheral blood mononuclear cells; antibodies;
D O I：
10.1007/s004300100092
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have implicated Chlamydia pneumoniae (now Chlamydophila pneumoniae) in the pathogenesis of atherosclerosis and demonstrated its presence within human peripheral blood mononuclear cells (PBMCs). In this study the presence of C. pneumoniae DNA was assessed, using nested PCR, in PBMCs from 169 active blood donors as a function of age, of specific antibodies and C-reactive protein. The results obtained demonstrated a high degree of global positivity (46.15%), which leas higher in females (52%) than in males (43.7%). Seroepidemiological studies showed a high percentage of positivity both in subjects positive by PCR (65.91%) and negative by PCR (71.74%). The clinical implication of such finding are under study.
引用
收藏
页码：139 / 144
页数：6
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