Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men

被引:70
|
作者
Ryan, Amy T.
Luscombe-Marsh, Natalie D.
Saies, Alexander A.
Little, Tanya J.
Standfield, Scott
Horowitz, Michael
Feinle-Bisset, Christine
机构
[1] Univ Adelaide, Discipline Med, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Natl Hlth, Adelaide, SA 5000, Australia
[3] Univ Adelaide, MRC, Australia Ctr Res Excellence Translating Nutr Sci, Adelaide, SA 5000, Australia
来源
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
ANTROPYLORODUODENAL MOTILITY; PLASMA CHOLECYSTOKININ; HEALTHY-MEN; FOOD-INTAKE; FUNCTIONAL DYSPEPSIA; AMINO-ACIDS; PEPTIDE YY; OBESE MEN; INSULIN RESPONSES; BLOOD-GLUCOSE;
D O I
10.3945/ajcn.113.061333
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Intraduodenal lipid modulates gastrointestinal motility and hormone release and suppresses energy intake (El) more than does intraduodenal glucose. Oral protein is the most satiating macronutrient and modulates postprandial glycemia; the comparative effects of intraduodenal protein and lipid and their combined effects are unclear. Objective: We investigated the effects of intraduodenal protein and lipid, alone or in combination, on antropyloroduodenal motility, gastrointestinal hormone release, glycemia, and EI. Design: Twenty lean men were studied on 5 randomized, double-blind occasions. Antropyloroduodenal motility, cholecystokinin, glucagon-like peptide-1 (GLP-1), insulin, glucagon, blood glucose, appetite, and nausea were measured during 90-min isocaloric (3 kcal/min) intraduodenal infusions of lipid [pure lipid condition (L3)], protein [pure protein condition (P3)], a 2:1 combination of lipid and protein [2:1 lipid:protein condition (L2P1)], a 1:2 combination of lipid and protein [1:2 lipid:protein condition (L1P2)], or a control. Immediately after the infusion, El from a buffet lunch was quantified. Results: In comparison with the control, all nutrient infusions suppressed antral and duodenal and stimulated pyloric pressures (P < 0.05). Cholecystokinin and GLP-1 release and pyloric stimulation were lipid-load dependent (r >= 0.39, P < 0.01), insulin and glucagon releases were protein-load dependent (r = 0.83, P < 0.001), and normoglycemia was maintained. L3 but not P3 increased nausea (P < 0.05). Compared with the control, L3 and P3 but not L2P1 or L1P2 suppressed El (P < 0.05) without major effects on appetite. Conclusions: In lean men, despite differing effects on gut function, intraduodenal lipid and protein produce comparable reductions in energy intake. The effects of lipid may be a result of nausea. Protein also regulates blood glucose by stimulating insulin and glucagon. In contrast, at the loads selected, lipid:protein combinations did not suppress energy intake, suggesting that a threshold load is required to elicit effects. This trial was registered at Australia and New Zealand Clinical Trial Registry (http://www.anzctr.org.au) as 12609000949280.
引用
收藏
页码:300 / 311
页数:12
相关论文
共 50 条
  • [1] Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men
    Ryan, Amy T.
    Feinle-Bisset, Christine
    Kallas, Asimina
    Wishart, Judith M.
    Clifton, Peter M.
    Horowitz, Michael
    Luscombe-Marsh, Natalie D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (03): : 474 - 482
  • [2] Comparative effects of intraduodenal whey protein hydrolysate on antropyloroduodenal motility, gut hormones, glycemia, appetite, and energy intake in lean and obese men
    Hutchison, Amy T.
    Feinle-Bisset, Christine
    Fitzgerald, Penelope C. E.
    Standfield, Scott
    Horowitz, Michael
    Clifton, Peter M.
    Luscombe-Marsh, Natalie D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2015, 102 (06): : 1323 - 1331
  • [3] Acute load-dependent effects of oral whey protein on gastric emptying, gut hormone release, glycemia, appetite, and energy intake in healthy men
    Hutchison, Amy T.
    Piscitelli, Diana
    Horowitz, Michael
    Jones, Karen L.
    Clifton, Peter M.
    Standfield, Scott
    Hausken, Trygve
    Feinle-Bisset, Christine
    Luscombe-Marsh, Natalie D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2015, 102 (06): : 1574 - 1584
  • [4] Effects of acute and longer-term dietary restriction on upper gut motility, hormone, appetite, and energy-intake responses to duodenal lipid in lean and obese men
    Seimon, Radhika V.
    Taylor, Pennie
    Little, Tanya J.
    Noakes, Manny
    Standfield, Scott
    Clifton, Peter M.
    Horowitz, Michael
    Feinle-Bisset, Christine
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 99 (01): : 24 - 34
  • [5] Effects of intraduodenal protein on appetite, energy intake, and antropyloroduodenal motility in healthy older compared with young men in a randomized trial
    Soenen, Stijn
    Giezenaar, Caroline
    Hutchison, Amy T.
    Horowitz, Michael
    Chapman, Ian
    Luscombe-Marsh, Natalie D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 100 (04): : 1108 - 1115
  • [6] Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility, hormone release, and appetite in healthy males
    Seimon, Radhika V.
    Feltrin, Kate L.
    Meyer, James H.
    Brennan, Ixchel M.
    Wishart, Judith M.
    Horowitz, Michael
    Feinle-Bisset, Christine
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2009, 296 (04) : R912 - R920
  • [7] Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men
    Little, TJ
    Feltrin, KL
    Horowitz, M
    Smout, AJPM
    Rades, T
    Meyer, JH
    Pilichiewicz, AN
    Wishart, J
    Feinle-Bisset, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 289 (04) : R1090 - R1098
  • [8] Contributions of upper gut hormones and motility to the energy intake-suppressant effects of intraduodenal nutrients in healthy, lean men - a pooled-data analysis
    Schober, Gudrun
    Lange, Kylie
    Steinert, Robert E.
    Hutchison, Amy T.
    Luscombe-Marsh, Natalie D.
    Landrock, Maria F.
    Horowitz, Michael
    Seimon, Radhika V.
    Feinle-Bisset, Christine
    [J]. PHYSIOLOGICAL REPORTS, 2016, 4 (17):
  • [9] Effects of intraduodenal coadministration of lauric acid and leucine on gut motility, plasma cholecystokinin, and energy intake in healthy men
    McVeay, Christina
    Steinert, Robert E.
    Fitzgerald, Penelope C. E.
    Ulrich, Sina S.
    Horowitz, Michael
    Feinle-Bisset, Christine
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2020, 318 (04) : R790 - R798
  • [10] The acute effects of four protein meals on insulin, glucose, appetite and energy intake in lean men
    Pal, Sebely
    Ellis, Vanessa
    [J]. BRITISH JOURNAL OF NUTRITION, 2010, 104 (08) : 1241 - 1248