The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone

被引：16
|
作者：
Slaney, Clare Y. [1 ,2 ]
Moeller, Andreas [1 ,2 ,3 ]
Hertzog, Paul J. [5 ]
Parker, Belinda S. [1 ,2 ,4 ]
机构：
[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Australia
[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia
[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
[4] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3052, Australia
[5] Monash Univ, Monash Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic, Australia
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期
关键词：
bone metastasis; breast cancer; interferon; tumor immune surveillance;
D O I：
10.4161/onci.22339
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer spread to distant sites is often incurable. Our recent findings demonstrate that Type I interferons secreted by tumor cells induce anti-metastatic immune responses that prevent breast cancer metastasis to the bone. This provides novel insights into the importance of the crosstalk between neoplastic and immune cells in the metastatic process.
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页数：3
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