Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics

被引：113

作者：

Ding, B ^{[1
]}

Guan, QY ^{[1
]}

Walsh, JP ^{[1
]}

Boswell, JS ^{[1
]}

Winter, TW ^{[1
]}

Winter, ES ^{[1
]}

Boyd, SS ^{[1
]}

Li, CH ^{[1
]}

Savage, PB ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 03期

关键词：

D O I：

10.1021/jm0105070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antibacterial activities of cationic steroid antibiotics and cationic peptide antibiotics have been compared. Depolarization of bacterial membranes, activation of bacterial stress-related gene promoters, and changes in bacterial morphologies caused by these antibiotics suggest that cationic steroid and peptide antibiotics share mechanistic aspects. Modified cationic steroid antibiotics display improved selectivity for prokaryotic cells over eukaryotic cells presumably due to increased charge recognition.

引用

页码：663 / 669

页数：7

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