Synthesis of imidazo[2,1-a]phthalazines, potential inhibitors of p38 MAP kinase.: Prediction of binding affinities of protein Ligands

被引：0

作者：

Mavel, S ^{[1
]}

Thery, I ^{[1
]}

Gueiffier, A ^{[1
]}

机构：

[1] Fac Pharm, Chim Therapeut Lab, F-37200 Tours, France

来源：

ARCHIV DER PHARMAZIE | 2002年 / 335卷 / 01期

关键词：

imidazophthalazine; Suzuki coupling; molecular modeling; p38; MAPK;

D O I：

10.1002/1521-4184(200201)335:1<7::AID-ARDP7>3.0.CO;2-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen-activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2,1-a]phthalazines obtained by Suzuki coupling are described.

引用

页码：7 / 14

页数：8

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