Accounting for Time: Circadian Rhythms in the Time of COVID-19

被引：13

作者：

Sengupta, Shaon ^{[1
,2
,3
,4
]}

Brooks, Thomas G. ^{[3
]}

Grant, Gregory R. ^{[3
,5
]}

FitzGerald, Garret A. ^{[3
,4
,6
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Neonatol, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Translat Med & Therapeut ITMAT, Philadelphia, PA 19104 USA

[4] Univ Penn, Chronobiol & Sleep Inst, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Syst Pharmacol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 2021年 / 36卷 / 01期

关键词：

vaccines; translational medicine; chronotherapy; COVID-19; circadian; immunity; GENE-EXPRESSION; REV-ERB; CLOCK; IMMUNITY; INNATE; MOUSE;

D O I：

10.1177/0748730420953335

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The COVID-19 pandemic has necessitated novel approaches and collaborative efforts across multiple disciplines. It is known that various aspects of our physiology and response to pathogens are under tight clock control. However, the assimilation of circadian biology into our clinical and research practices is still evolving. Using a focused review of the literature and original analyses of the UK Biobank, we discuss how circadian biology may inform our diagnostic and therapeutic strategies in this pandemic.

引用

页码：4 / 8

页数：5

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