Inhibition of T-cell responses by CD4 on an antigen-presenting cell

被引：2

作者：

Hansen, T ^{[1
]}

机构：

[1] Univ Bergen, Dept Microbiol & Immunol, Gade Inst, N-5021 Bergen, Norway

来源：

APMIS | 2006年 / 114卷 / 01期

关键词：

CD4; T-cell activation; antigen-presenting cells;

D O I：

10.1111/j.1600-0463.2006.apm_339.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to T-helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen-presenting cells affect T-cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions. We found that expression of CD4 on Raji had an inhibitory effect on production of IFN-gamma and other cytokines.

引用

页码：32 / 38

页数：7

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