Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients

被引:12
|
作者
Zhuo HongQing [1 ]
Jiang KeWei [1 ]
Dong LingYi [1 ]
Zhu Yi [1 ]
Lu Liang [1 ]
Lu You [1 ]
Zhang YanBin [1 ]
Zhang Hui [1 ]
Ye YingJiang [1 ]
Wang Shan [1 ]
机构
[1] Peking Univ, Dept Gastrointestinall Surg, Lab Surg Oncol, Peoples Hosp, Beijing 100044, Peoples R China
来源
CHINESE SCIENCE BULLETIN | 2013年 / 58卷 / 28-29期
基金
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词
colorectal neoplasms; N-cadherin; immunohistochemistry; prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CELL-ADHESION; PROSTATE-CANCER; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; TUMOR-METASTASIS; EXPRESSION; MIGRATION; INVASION; IDENTIFICATION;
D O I
10.1007/s11434-013-5813-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
N-cadherin is related to the progression and metastases of several solid carcinomas. However, it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency. In this study, we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120 patients with colorectal cancer. We revealed that N-cadherin was expressed in 78.3% (94/120) of colorectal tumor tissues and in only 9.2% (11/120) of paired distant normal mucosa tissues with a significant difference (P=0.000). The low, moderate, and high expression of N-cadherin protein was 42.5%, 30.8%, and 26.7%, respectively. N-cadherin overexpression was associated with advanced TNM stage, lymph nodes metastasis and distant metastasis (P < 0.05). Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression, and patients with low expression had a better survival rate than those with moderate and high expression (P < 0.05). In conclusion, high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer, and may prove to be a possible prognostic factor.
引用
收藏
页码:3529 / 3534
页数:6
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