Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

被引：290

作者：

Barouch, Dan H. ^{[1
,2
]}

Stephenson, Kathryn E. ^{[1
]}

Borducchi, Erica N. ^{[1
]}

Smith, Kaitlin ^{[1
]}

Stanley, Kelly ^{[1
]}

McNally, Anna G. ^{[1
]}

Liu, Jinyan ^{[1
]}

Abbink, Peter ^{[1
]}

Maxfield, Lori F. ^{[1
]}

Seaman, Michael S. ^{[1
]}

Dugast, Anne-Sophie ^{[2
]}

Alter, Galit ^{[2
]}

Ferguson, Melissa ^{[3
]}

Li, Wenjun ^{[4
]}

Earl, Patricia L. ^{[5
]}

Moss, Bernard ^{[5
]}

Giorgi, Elena E. ^{[6
]}

Szinger, James J. ^{[6
]}

Eller, Leigh Anne ^{[7
]}

Billings, Erik A. ^{[7
]}

Rao, Mangala ^{[7
]}

Tovanabutra, Sodsai ^{[7
]}

Sanders-Buell, Eric ^{[7
]}

Weijtens, Mo ^{[8
]}

Pau, Maria G. ^{[8
]}

Schuitemaker, Hanneke ^{[8
]}

Robb, Merlin L. ^{[7
]}

Kim, Jerome H. ^{[7
]}

Korber, Bette T. ^{[6
]}

Michael, Nelson L. ^{[7
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Ragon Inst MGH Massachusetts Inst Technol & Harva, Boston, MA 02114 USA

[3] Alpha Genesis Inc, Yemassee, SC 29945 USA

[4] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

[5] NIAID, Bethesda, MD 20892 USA

[6] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[7] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA

[8] Crucell Holland BV, NL-2301 CA Leiden, Netherlands

来源：

CELL | 2013年 / 155卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTE RESPONSES; IMMUNE CONTROL; BREADTH; AIDS; IMMUNOGENICITY; DIVERSITY; INFECTION; MACAQUES; COVERAGE;

D O I：

10.1016/j.cell.2013.09.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed for improved coverage of HIV-1 diversity. However, the protective efficacy of such global HIV-1 vaccine antigens has not previously been evaluated. Here, we demonstrate the capacity of bivalent HIV-1 mosaic antigens to protect rhesus monkeys against acquisition of infection following heterologous challenges with the difficult-to-neutralize simian-human immunodeficiency virus SHIV-SF162P3. Adenovirus/poxvirus and adenovirus/adenovirus vector-based vaccines expressing HIV-1 mosaic Env, Gag, and Pol afforded a significant reduction in the per-exposure acquisition risk following repetitive, intrarectal SHIV-SF162P3 challenges. Protection against acquisition of infection correlated with vaccine-elicited binding, neutralizing, and functional nonneutralizing antibodies, suggesting that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralize viruses. These data demonstrate the protective efficacy of HIV-1 mosaic antigens and suggest a potential strategy for the development of a global HIV-1 vaccine.

引用

页码：531 / 539

页数：9

共 50 条

[1] Protective Efficacy of Candidate Clinical HIV-1 Vaccine Regimens Against SHIV-SF162P3 Challenges in Rhesus Monkeys
Wegmann, Frank
Alter, Galit
Nkolola, Joseph P.
Stephenson, Kathryn E.
Borducchi, Erica N.
Cabral, Crystal
Seaman, Michael S.
Zahn, Roland
Weijtens, Mo
Michael, Nelson L.
Robb, Merlin L.
Pau, Maria G.
Schuitemaker, Hanneke
Barouch, Dan H.
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 68 - 68
[2] SHIV Infection Protects Against Heterologous Pathogenic SHIV Challenge in Macaques: A Gold-Standard for HIV-1 Vaccine Development?
Sealy, Robert
Zhan, Xiaoyan
Lockey, Timothy D.
Martin, Louis
Blanchard, James
Traina-Dorge, Vicki
Hurwitz, Julia L.
[J]. CURRENT HIV RESEARCH, 2009, 7 (05) : 497 - 503
[3] Efficacy of a Trimeric Envelope Protein Vaccine From an Indian Clade C HIV-1 Isolate Against Heterologous Clade C SHIV Isolate Challenges in Macaques
Ayala, Victor
Menon, Veena
Rangasamy, Sneha Priya
Ashraf, Asma
O'Neill, Corinne
Galmin, Lindsey
Santra, Sampa
Ortiz, Abel
Labranche, Celia
Montefiori, David
Kalyanaraman, V. S.
Pal, Ranajit
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2018, 34 : 354 - 354
[4] Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges
Rasmussen, Robert A.
Ong, Helena
Song, Ruijiang
Chenine, Agnes-Laurence
Ayash-Rashkovsky, Mila
Hu, Shiu-Lok
Polacino, Patricia
Else, James G.
Novembre, Francis J.
Ruprecht, Ruth A.
[J]. AIDS, 2007, 21 (14) : 1841 - 1848
[5] Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys
Barouch, Dan H.
Alter, Galit
Broge, Thomas
Linde, Caitlyn
Ackerman, Margaret E.
Brown, Eric P.
Borducchi, Erica N.
Smith, Kaitlin M.
Nkolola, Joseph P.
Liu, Jinyan
Shields, Jennifer
Parenteau, Lily
Whitney, James B.
Abbink, Peter
Ng'ang'a, David M.
Seaman, Michael S.
Lavine, Christy L.
Perry, James R.
Li, Wenjun
Colantonio, Arnaud D.
Lewis, Mark G.
Chen, Bing
Wenschuh, Holger
Reimer, Ulf
Piatak, Michael
Lifson, Jeffrey D.
Handley, Scott A.
Virgin, Herbert W.
Koutsoukos, Marguerite
Lorin, Clarisse
Voss, Gerald
Weijtens, Mo
Pau, Maria G.
Schuitemaker, Hanneke
[J]. SCIENCE, 2015, 349 (6245) : 320 - 324
[6] Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge
Om, Kier
Paquin-Proulx, Dominic
Montero, Maria
Peachman, Kristina
Shen, Xiaoying
Wieczorek, Lindsay
Beck, Zoltan
Weiner, Joshua A.
Kim, Dohoon
Li, Yifan
Mdluli, Thembi
Shubin, Zhanna
Bryant, Christopher
Sharma, Vishakha
Tokarev, Andrey
Dawson, Peter
White, Yohann
Appelbe, Oliver
Klatt, Nichole R.
Tovanabutra, Sodsai
Estes, Jacob D.
Matyas, Gary R.
Ferrari, Guido
Alving, Carl R.
Tomaras, Georgia D.
Ackerman, Margaret E.
Michael, Nelson L.
Robb, Merlin L.
Polonis, Victoria
Rolland, Morgane
Eller, Michael A.
Rao, Mangala
Bolton, Diane L.
[J]. PLOS PATHOGENS, 2020, 16 (09)
[7] Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys
Zhang, Lishu
Jin, Ningyi
Song, Yingjin
Sun, Yansong
Wang, Hong
Zhan, Dawei
Ma, Hewen
Shang, Yupu
Jin, Hongtao
Hong, Baoqing
Chang, Li
[J]. CHINESE SCIENCE BULLETIN, 2006, 51 (13): : 1571 - 1577
[8] Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys
ZHANG Lishu1
2. College of Agricultural and Biological Engineer
3. Laboratory Animal Center
4. College of Life Science
5. Agricultural Sciences Center
[J]. Science Bulletin, 2006, (13) : 1571 - 1577
[9] Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Abbink, Peter
Larocca, Rafael A.
De La Barrera, Rafael A.
Bricault, Christine A.
Moseley, Edward T.
Boyd, Michael
Kirilova, Marinela
Li, Zhenfeng
Ng'ang'a, David
Nanayakkara, Ovini
Nityanandam, Ramya
Mercado, Noe B.
Borducchi, Erica N.
Agarwal, Arshi
Brinkman, Amanda L.
Cabral, Crystal
Chandrashekar, Abishek
Giglio, Patricia B.
Jetton, David
Jimenez, Jessica
Lee, Benjamin C.
Mojta, Shanell
Molloy, Katherine
Shetty, Mayuri
Neubauer, George H.
Stephenson, Kathryn E.
Peron, Jean Pierre S.
Zanotto, Paolo M. de A.
Misamore, Johnathan
Finneyfrock, Brad
Lewis, Mark G.
Alter, Galit
Modjarrad, Kayvon
Jarman, Richard G.
Eckels, Kenneth H.
Michael, Nelson L.
Thomas, Stephen J.
Barouch, Dan H.
[J]. SCIENCE, 2016, 353 (6304) : 1129 - 1132
[10] Control of SHIV-89.6P infection of cynomolgus monkeys by an HIV-1 Tat vaccine
Ensoli, B
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (18) : 1615 - 1616

← 1 2 3 4 5 →