Facile one-pot tandem synthesis of perfluoroalkylated indolizines under metal-free mild conditions

被引：9
|
作者：
He, Dong [1 ]
Xu, Yuhong [1 ]
Han, Jing [1 ]
Deng, Hongmei [2 ]
Shao, Min [2 ]
Chen, Jie [1 ]
Zhang, Hui [1 ,2 ]
Cao, Weiguo [1 ,3 ,4 ,5 ]
机构：
[1] Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China
[2] Shanghai Univ, Lab Microstruct, Instrumental Anal & Res Ctr, Shanghai 200444, Peoples R China
[3] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
[4] Chinese Acad Sci, Key Lab Synthet Organ Chem Nat Subst, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
[5] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Indolizine; Perfluoroalkylated; One-pot reaction; Metal-free; Tandem synthesis; 1,3-DIPOLAR CYCLOADDITION; PYRIDINIUM YLIDES; PERFLUOROPROPENE; DERIVATIVES; ANNULATION; KETONES;
D O I：
10.1016/j.tet.2017.01.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct metal-free method for the synthesis of perfluoroalkylated indolizines by means of DIPEA-promoted tandem C-N/C-C bond formation was developed. Various substituted pyridines and bromoacetyl derivatives with methyl perfluoroalk-2-ynoates proceeded smoothly in this mild transformation, and the desired products were obtained in good to excellent yields under air. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：938 / 944
页数：7
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