Influence of Interleukin 1α (IL-1α), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis

被引：28
|
作者：
Tsezou, Aspasia [1 ,2 ]
Poultsides, Lazaros [3 ]
Kostopoulou, Fotini [1 ]
Zintzaras, Elias [4 ]
Satra, Maria [6 ]
Kitsiou-Tzeli, Sofia [5 ]
Malizos, Konstantinos N. [2 ,3 ]
机构：
[1] Univ Thessalia, Sch Med, Dept Biol, Lab Cytogenet & Mol Genet, Mezourlo 41222, Larissa, Greece
[2] Inst Biomed Res & Technol, Larisa, Greece
[3] Univ Thessalia, Sch Med, Dept Orthopaed, Larisa, Greece
[4] Univ Thessalia, Sch Med, Dept Bioinformat, Larisa, Greece
[5] Univ Athens, Dept Med Genet, Athens, Greece
[6] Univ Thessalia, Sch Med, Dept Biol, Larisa, Greece
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2008年 / 15卷 / 12期
关键词：
D O I：
10.1128/CVI.00209-08
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1 alpha (IL-1 alpha) -889-C/T, IL-4 -1098-G/T and -590-C/T, and IL-6 -174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.
引用
收藏
页码：1888 / 1890
页数：3
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