Two multidrug-resistant Salmonella Infantis isolates behave like hypo-invasive strains but have high intracellular proliferation

被引：0
|
作者：
Di Conza, Jose A. [1 ,2 ]
Mollerach, Marta E.
Gutkind, Gabriel O.
Ayala, Juan A. [3 ]
机构：
[1] Univ Buenos Aires, Fac Farm & Bioquim, RA-1113 Buenos Aires, DF, Argentina
[2] Univ Nacl Litoral, Fac Bioquim Ciencias Biol, RA-3000 Santa Fe, Argentina
[3] CSIC, Ctr Biol Mol Sever Ochoa, Madrid 28049, Spain
来源：
REVISTA ARGENTINA DE MICROBIOLOGIA | 2012年 / 44卷 / 02期
关键词：
Salmonella Infantis; multiresistance; invasion ability; intracellular proliferation; VIRULENCE PLASMIDS; NONTYPHOID SALMONELLA; TYPHIMURIUM;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two multidrug-resistant Salmonella Infantis isolates behave like hypo-invasive strains but have high intracellular proliferation. In this work, plasmid-encoded virulence factors in two Salmonella Infantis isolates carrying multiresistance plasmids were investigated. In addition, their invasion and proliferative ability in non-phagocytic cells was studied. None of them showed the typical determinants of virulence plasmids (spy operon). The invasion assays of S. Infantis isolates on eukaryotic cells showed a decreased ability to invade but they remained and proliferated in the cytoplasm regardless of having used a permissive (HeLa) or non-permissive (NRK) cell line. Finally, there was no microscopic evidence suggesting a bactericidal effect of these eukaryotic cell lines on the isolates tested.
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收藏
页码：69 / 74
页数：6
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