Evaluation of oxidative stress among coronary patients

被引：2
|
作者：
Gammoudi, I. [1 ]
Dandana, A. [1 ]
Chahed, H. [1 ]
Ferchichi, S. [1 ]
Ernez, S. [2 ]
Miled, A. [1 ]
机构：
[1] CHU Farhat Hached, Lab Biochim, Sousse 4000, Tunisia
[2] CHU Farhat Hached, Serv Cardiol, Sousse 4000, Tunisia
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2013年 / 28卷 / 01期
关键词：
Coronary syndrome; Homocysteine; Oxidant; Antioxidant; Free radical; LIPID-PEROXIDATION; MALONDIALDEHYDE; MARKER; HYPERHOMOCYSTEINEMIA; DISEASE; BLOOD;
D O I：
10.1016/j.immbio.2012.10.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective.-The present study was undertaken to evaluate the variation of the parameters of antioxidant and oxidant status in coronary patients. Patients and methods.-Two hundred and eighteen patients with unstable angina (UA) and 183 healthy control subjects were admitted. Oxidant status was evaluated by measuring homocysteine and thiobarbituric reactive oxygen substances (TROS). Antioxidant status was evaluated by measuring superoxide dismutase (SOD) activity and glutathione peroxidase (GPx). Results.-Homocysteine (Hcy) and thiobarbituric acid reactive substances (TROS) levels were significantly higher in coronary patients compared with healthy control subjects. SOD and GPX were significantly decreased among patients compared to the controls. In addition, coronary patients showed significant negatives correlations between Hcy-SOD, Hcy-GPx and TBARS-SOD, TBARS-GPx. Conclusion.-Our patients present an increasing oxidative stress but the defences antioxidants tended to be decreased. (c) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：39 / 42
页数：4
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