Children's Oncology Group's 2013 blueprint for research: Bone tumors

被引：152
|
作者：
Gorlick, Richard [1 ,2 ]
Janeway, Katherine [3 ]
Lessnick, Stephen [4 ]
Randall, R. Lor [5 ,6 ]
Marina, Neyssa [7 ,8 ]
机构：
[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Pediat & Mol Pharmacol, Bronx, NY 10467 USA
[2] Childrens Hosp Montefiore, Div Pediat Hematol Oncol, Bronx, NY 10467 USA
[3] Dana Farber Childrens Hosp Canc Ctr, Dept Pediat Hematol Oncol, Boston, MA USA
[4] Univ Utah, Sch Med, Dept Oncol Sci,Div Pediat Hematol Oncol, Ctr Childrens Canc Res,Huntsman Canc Inst, Salt Lake City, UT USA
[5] Univ Utah, Orthopaed Huntsman Canc Inst, Salt Lake City, UT USA
[6] Univ Utah, Primary Childrens Med Ctr, Salt Lake City, UT USA
[7] Lucile Packard Childrens Hosp, Palo Alto, CA USA
[8] Stanford Univ, Palo Alto, CA 94304 USA
来源：
PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 06期
关键词：
blueprint; bone sarcoma; Ewing sarcoma; osteosarcoma; FACTOR-I-RECEPTOR; EWING SARCOMA FAMILY; PRIMITIVE NEUROECTODERMAL TUMOR; ONCOGENIC TRANSCRIPTION FACTOR; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; MURAMYL TRIPEPTIDE; PROGNOSTIC-FACTORS; PHASE-II; METASTATIC OSTEOSARCOMA;
D O I：
10.1002/pbc.24429
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing sarcoma (ES) each year. Five-year survival ranges from 65% to 75% for localized disease and <30% for patients with metastases. Recent findings include interval-compressed five drug chemotherapy improves survival with localized ES. In osteosarcoma a large international trial investigating the addition of ifosfamide/etoposide or interferon to standard therapy has completed accrual. For ES an ongoing trial explores the addition of cyclophosphamide/topotecan to interval-compressed chemotherapy. Trials planned by the Children's Oncology Group will investigate new target(s) including IGF-1R and mTOR in ES, and RANKL and GD2 in osteosarcoma. Pediatr Blood Cancer 2013; 60: 10091015. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：1009 / 1015
页数：7
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