Oxidative Stress and Rho-Associated Coiled-Coil Protein Kinase (ROCK)-Mediated Double Phosphorylation of Myosin Light Chain in the Submembranous Region Plays a Key Role in Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells

被引：0

作者：

Hirano, Mayumi ^{[1
]}

Hanada, Akiko ^{[1
]}

Hirano, Katsuya ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Div Mol Cardiol, Fukuoka 812, Japan

来源：

CIRCULATION | 2012年 / 126卷 / 21期

关键词：

Endothelial; Myosin; Thrombin;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

12898

引用

页数：1

共 9 条

[1] Ca2+-Independent Di-phosphorylation of Myosin Light Chain by Rho-associated Coiled-Coil Protein Kinase (ROCK) in the Subjunctional Regions of Cell-Cell Contact Mediates Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells
Hirano, Mayumi
Hanada, Akiko
Hirano, Katsuya
CIRCULATION, 2011, 124 (21)
[2] Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction
Hirano, Mayumi
Hanada, Akiko
Hirano, Katsuya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 245P - 245P
[3] Rho-associated Kinase (ROCK) Mediates the Thrombin-Induced Production of Reactive Oxygen Species and Myosin Light Chain Phosphorylation-Independent Vasoconstriction in the Pulmonary Artery
Hirano, Katsuya
Maki, Jun
Hirano, Mayumi
CIRCULATION, 2010, 122 (21)
[4] Di-Phosphorylation of Myosin Light Chain and Actin fiber formation in the Submembranous Region at Inter-endothelial Junction Play a Crucial Role in Thrombin-induced Endothelial Barrier Disruption
Hirano, Mayumi
Hirano, Katsuya
CIRCULATION, 2013, 128 (22)
[5] Rho Kinase-mediated Di-phosphorylation of Myosin Light Chain in the Sub-membranous Regions and Circumferential Actomyosin Contraction Mediate Thrombin-induced Barrier Disruption in Vascular Endothelial Cells
Hirano, Mayumi
Hirano, Katsuya
STROKE, 2013, 44 (02)
[6] A Clock Gene RORα-mediated Regulation of the Activity of Rho-associated Coiled-coil Protein Kinase 2 (ROCK2) Plays a Key Role in Generating Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility
Saito, Toshiro
Hirano, Mayumi
Ide, Tomomi
Ichiki, Toshihiro
Koibuchi, Noriyuki
Sunagawa, Kenji
Hirano, Katsuya
CIRCULATION RESEARCH, 2012, 111 (12) : E382 - E382
[7] orexin B alleviates sepsis-associated lung injury through the attenuation of pulmonary endothelial barrier dysfunction by regulating the rho-associated coiled-coil containing protein kinase 2/zonula occludens-1 (ROCK2/ZO-1) axis
Wang, Yiyuan
Wan, Xiaohong
Li, Yusheng
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2024,
[8] Oxycodone relieves permeability damage and apoptosis of oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cells through ras homolog family member A (RhoA)/Rho-associated coiled-coil containing kinases (ROCK)/myosin light chain 2 (MLC2) signal
Shao, Fang
Han, Dong
Shen, Yihui
Bian, Wen
Zou, Liting
Hu, Yiqian
Sun, Wei
BIOENGINEERED, 2022, 13 (03) : 5205 - 5215
[9] FSD-C10 Shows Therapeutic Effects in Suppressing oxidized low-density lipoprotein (ox-LDL)-Induced Human Brain Microvascular Endothelial Cells Apoptosis via Rho-Associated Coiled-Coil Kinase (ROCK)/Mitogen-Activated Protein Kinase (MAPK) Signaling
Wang, Xin
Mao, Rongyan
Chen, Weiwei
MEDICAL SCIENCE MONITOR, 2018, 24 : 5509 - 5516

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