A Vesicular Stomatitis Virus-Inspired DNA Nanocomplex for Ovarian Cancer Therapy

被引：23

作者：

Zhao, Wei ^{[1
,2
,3
,4
,5
]}

Yang, Yuping ^{[1
,2
,3
]}

Song, Lingling ^{[6
]}

Kang, Tianyi ^{[1
,2
,3
]}

Du, Ting ^{[1
,2
,3
]}

Wu, Yujiao ^{[1
,2
,3
]}

Xiong, Meimei ^{[1
,2
,3
]}

Luo, Li ^{[1
,2
,3
]}

Long, Jianlin ^{[4
,5
]}

Men, Ke ^{[1
,2
,3
]}

Zhang, Lan ^{[7
]}

Chen, Xiaoxin ^{[7
]}

Huang, Meijuan ^{[1
,2
,3
,4
,5
]}

Gou, Maling ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Canc Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[3] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, Dept Thorac Oncol, Canc Ctr, West China Hosp,West China Med Sch, Chengdu 610041, Sichuan, Peoples R China

[5] Sichuan Univ, State Key Lab Biotherapy, West China Hosp, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China

[6] Shenzhen Longhua New Dist Cent Hosp, Community Hlth Serv Adm Ctr, Shenzhen 518110, Peoples R China

[7] Guangdong Zhongsheng Pharm, Res & Dev Dept, Dongguan 523325, Peoples R China

来源：

ADVANCED SCIENCE | 2018年 / 5卷 / 03期

基金：

国家重点研发计划;

关键词：

bioinspiration; cancer therapy; gene delivery; nanoparticles; ovarian cancer; MATRIX PROTEIN; GENE-THERAPY; EFFICIENT INHIBITION; ONCOLYTIC VIRUSES; PROLONGED SURVIVAL; PRIMARY SURGERY; TARGET GENES; RNA; NANOPARTICLE; CHEMOTHERAPY;

D O I：

10.1002/advs.201700263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gene therapy provides a novel method for cancer therapy. This study shows a DNA nanocomplex that is inspired from vesicular stomatitis virus (VSV) for ovarian cancer therapy. This DNA nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)-poly (d, l-lactide) (MPEG-PLA) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (VSVMP) that plays a critical role in the VSV-induced apoptosis of cancer cells. The cationized MPEG-PLA nanoparticle that is self-assembled by MPEG-PLA copolymer and N-[1-(2,3-dioleoyloxy) propyl]-N, N, N-trimethylammonium chloride (DOTAP) has low cytotoxicity and high transfection efficiency (>80%). Intraperitoneal administration of the pVSVMP nanocomplex remarkably inhibits the intraperitoneal metastasis of ovarian cancer and does not cause significant systemic toxicity. The apoptosis induction and anti-angiogenesis are involved in the anticancer mechanism. This work demonstrates a VSV-inspired DNA nanocomplex that has potential application for the treatment of intraperitoneal metastasis of ovarian cancer.

引用

页数：9

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