The type III secretion system of Pseudomonas aeruginosa: infection by injection

被引：663
|
作者：
Hauser, Alan R. [1 ,2 ]
机构：
[1] Northwestern Univ, Dept Microbiol Immunol, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Med, Chicago, IL 60611 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 09期
基金：
美国国家卫生研究院;
关键词：
GTPASE-ACTIVATING PROTEIN; VENTILATOR-ASSOCIATED PNEUMONIA; ADP-RIBOSYLTRANSFERASE DOMAIN; ACTIN CYTOSKELETON DISRUPTION; GUANINE-NUCLEOTIDE EXCHANGE; EXOENZYME-S; IN-VIVO; CYSTIC-FIBROSIS; YERSINIA-ENTEROCOLITICA; EPITHELIAL-CELLS;
D O I：
10.1038/nrmicro2199
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.
引用
收藏
页码：654 / 665
页数：12
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