Romedepsin (RM), a HDACi, Significantly Increases the Expression of NKG2D Ligands, MIC A/B, in Leukemia/Lymphoma Cells (LL), in Part through the Glycogen Synthase Kinase-3 (GSK-3) Pathway, Resulting in Enhanced NK Cytotoxicity.

被引：0

|

作者：

Saha, Aniket ^{[1
]}

Bavishi, Sejal ^{[1
]}

Zhao, Frances ^{[1
]}

Ayello, Janet ^{[1
]}

van de Ven, Carmella ^{[1
]}

Satwani, Prakash ^{[1
]}

Cairo, Mitchell S. ^{[1
]}

机构：

[1] Columbia Univ, Morgan Stanley Childrens Hosp New York Presbyteri, Dept Pediat Pathol & Med, New York, NY USA

来源：

BLOOD | 2009年 / 114卷 / 22期

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D O I：

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中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

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页码：1179 / 1180

页数：2

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[1] ROMEDEPSIN (RM), A HDACI, SIGNIFICANTLY INCREASES THE EXPRESSION OF NKG2D LIGANDS, MIC A/B, IN LEUKEMIA/LYMPHOMA CELLS (LL), IN PART THROUGH THE GLYCOGEN SYNTHASE KINASE-3 (GSK-3) PATHWAY, RESULTING IN ENHANCED NK CYTOTOXICITY: TRANSLATIONAL APPROACH FOR ADOPTIVE NK CELL IMMUNOTHERAPY
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[2] Romedepsin (RM), a Histone Deacytelase Inhibitor (HDACi), Significantly Increases the Expression of NKG2D Ligands, MIC A/B, In Pediatric Leukemia/Lymphoma Cells (LL), Resulting In Enhanced In Vitro and In Vivo NK Cytotoxicity In NOD-SCID Mice: Translational Approach for Adoptive NK Cell Targeted Immunotherapy
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[3] Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell-Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3
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