Association of MMP-9 Gene polymorphisms with Glaucoma: A Meta-Analysis

被引：14

作者：

Zhang, Yiqun ^{[1
]}

Wang, Mingjie

Zhang, Sunyi ^{[1
]}

机构：

[1] Suzhou Univ, Affiliated Hosp, Dept Ophthalmol, Changzhou Peoples Hosp 4, 68 Honghe Rd, Changzhou 213001, Jiangsu, Peoples R China

来源：

OPHTHALMIC RESEARCH | 2016年 / 55卷 / 04期

关键词：

Glaucoma; Meta-analysis; MMP-9; Polymorphisms; Single-nucleotide polymorphisms; ANGLE-CLOSURE GLAUCOMA; SINGLE NUCLEOTIDE POLYMORPHISMS; MATRIX METALLOPROTEASE-9 GENE; EXTRACELLULAR-MATRIX; TRABECULAR MESHWORK; RISK-FACTORS; POPULATION; DISEASE; MATRIX-METALLOPROTEINASE-9; INHIBITORS;

D O I：

10.1159/000443627

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The aim of this study was to evaluate the associations between matrix metalloproteinase-9 (MMP-9) gene polymorphisms (rs17576 and rs3918249) and glaucoma risk. All eligible studies were searched in PubMed, Embase, the Cochrane Library and the China Knowledge Resource Integrated Database. Pooled odds ratios and 95% confidence intervals were used to assess associations between MMP-9 gene polymorphisms and glaucoma. Seven studies on rs17576 (1,357 cases and 1,432 controls) and 3 studies on rs3918249 (550 cases and 794 controls) were included. The results suggest that rs17576 was not associated with glaucoma risk based on current publications. However, stratification analyses indicated that GG genotypes increased the risk of primary open-angle glaucoma in a recessive model (GG vs. AA + AG). The rs3918249 polymorphism was also associated with a decreased risk of glaucoma, especially for Caucasian patients. To sum up, our data indicate that rs17576 polymorphism is not related to glaucoma and rs3918249 polymorphism might be a protective factor against glaucoma. (C) 2016 S. Karger AG, Basel

引用

页码：172 / 179

页数：8

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