Consecutive Five-Component Ugi-4CR-CAL B-Catalyzed Aminolysis Sequence and Concatenation with Transition Metal Catalysis in a One-Pot Fashion to Substituted Triamides

被引：6

作者：

Gesse, Pascal ^{[1
]}

Mueller, Thomas J. J. ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Organ Chem & Makromol Chem, Univ Str 1, D-40225 Dusseldorf, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 11期

关键词：

Aminolysis; Copper; Cross-coupling; Cycloaddition; Palladium; SOLUTION-PHASE PREPARATION; ANTARCTICA-LIPASE-B; CHEMOENZYMATIC SYNTHESIS; MULTICOMPONENT REACTIONS; ENZYMATIC DESYMMETRIZATION; ORGANIC-SYNTHESIS; UGI; COMBINATION; PEPTIDOMIMETICS; BIOCATALYSIS;

D O I：

10.1002/ejoc.201900198

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The concatenation of the Ugi four-component synthesis and the CAL B-catalyzed aminolysis of the intermediary formed Ugi methyl ester products furnishes a novel consecutive five-component reaction for the formation of triamides. This one-pot process is excellently compatible with metal catalyzed processes, such as copper-catalyzed alkyne-azide cycloaddition and Suzuki cross-coupling or both in a one-pot fashion. These novel consecutive six-component syntheses represent a practical tool for synthesizing substrate libraries of complex triamide structures in a diversity-oriented fashion.

引用

页码：2150 / 2157

页数：8