Gene expression profile of aging and its retardation by caloric restriction

被引：1177
|
作者：
Lee, CK
Klopp, RG
Weindruch, R
Prolla, TA
机构：
[1] VA Hosp, Dept Med, GRECC 4D, Madison, WI 53705 USA
[2] Univ Wisconsin, Ctr Environm Toxicol, Madison, WI 53706 USA
[3] Univ Wisconsin, Inst Aging, Madison, WI 53706 USA
[4] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA
[5] Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA
[6] Univ Wisconsin, Dept Med, Madison, WI USA
[7] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI USA
来源：
SCIENCE | 1999年 / 285卷 / 5432期
关键词：
D O I：
10.1126/science.285.5432.1390
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and Lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.
引用
收藏
页码：1390 / 1393
页数：4
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