Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat

被引：14
|
作者：
Lukkarinen, JA
Gröhn, OHJ
Alhonen, LI
Jänne, J
Kauppinen, RA [1 ]
机构：
[1] Univ Kuopio, AI Virtanen Inst Mol Sci, NMR Res Grp, FIN-70211 Kuopio, Finland
[2] Univ Kuopio, AI Virtanen Inst Mol Sci, Anim Biotechnol Grp, FIN-70211 Kuopio, Finland
来源：
BRAIN RESEARCH | 1999年 / 826卷 / 02期
基金：
芬兰科学院;
关键词：
ornithine decarboxylase; transgenic rat; magnetic resonance imaging; focal cerebral ischemia;
D O I：
10.1016/S0006-8993(99)01327-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ornithine decarboxylase (ODC) transgenic and alpha-difluoromethyl ornithine (DFMO)-treated rats were exposed to transient middle cerebral occlusion (MCAO) to examine the role of intraischaemic ODC-activity on the evolution of ischaemia-reperfusion damage. Magnetic resonance imaging (MRI) data show that the damage develops slower in ODC transgenic than in DFMO-treated rats, which is not caused by a difference in perfusion. Furthermore, infarct volumes are smaller in the former animals one day later. These data support the idea of endogenous neuroprotective action of ODC. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：325 / 329
页数：5
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