Design, synthesis, and biological activity of novel 4-(3,4dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives

被引：29
|
作者：
Liu, CL [1 ]
Li, L
Li, ZM
机构：
[1] Shenyang Res Inst Chem Ind, Agrochem Discovery Dept, Shenyang 110021, Peoples R China
[2] Nankai Univ, State Key Lab Elemento Organ Chem, Inst Elemento Organ Chem, Tianjin 300071, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 11期
关键词：
thiazolecarboxylic acid derivatives; synthesis; biological activity;
D O I：
10.1016/j.bmc.2004.03.050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives (11-23) were synthesized from 3,4-dimethoxyacetophenone (5) in six-step procedure. Their biological activities were evaluated in the greenhouse. Some of the compounds had shown fungicidal and insecticidal activities at 375 g ai/ha and 600 g ai/ha, respectively. 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2825 / 2830
页数：6
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