Hypervalent Iodine(III)-Mediated Benzannulation of Enamines with Alkynes for the Synthesis of Polysubstituted Naphthalene Derivatives

被引：45

作者：

Gao, Peng ^{[1
]}

Liu, Jinjian ^{[1
]}

Wei, Yunyang ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 11期

关键词：

N BOND FORMATION; CATALYZED 4+2 BENZANNULATION; IODINE REAGENT; C-H; OXIDATIVE CYCLIZATION; ORGANOIODINE COMPOUND; COUPLING REACTION; REACTIVITY; BIS(TRIFLUOROACETATE); CYCLOADDITION;

D O I：

10.1021/ol401206g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of functionalized 1-amino-2-naphthalenecarboxylic acid derivatives were synthesized from enamines and alkynes via a benzannulation strategy mediated by iodosylbenzene and BF3 center dot Et2O. The advantages of this novel benzannulation process include broad substrate scope, good functional group tolerance, and mild reaction conditions without the use of heavy metals.

引用

页码：2872 / 2875

页数：4

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