The use of novel water-in-oil microemulsions in microemulsion electrokinetic chromatography

被引：37
|
作者：
Altria, KD
Broderick, MF
Donegan, S
Power, J
机构：
[1] Waterford Inst Technol, Dept Chem & Life Sci, Waterford, Ireland
[2] GlaxoSmithKline, Pharmaceut Dev, Harlow, Essex, England
来源：
ELECTROPHORESIS | 2004年 / 25卷 / 4-5期
关键词：
microemulsion electrokinetic chromatography; water-in-oil emulsion;
D O I：
10.1002/elps.200305789
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe the novel use of water-in-oil (W/O) microemulsions to achieve unique separations in microemulsion electrokinetic chromatography (MEEKC). The choise and concentration of the buffer type, surfactant and co-surfactant were all examined and optimized. Separations of a range of neutral and acidic analytes was shown to be markedly different to that obtained by (oil-in-water) O/W MEEKC. Neutral solutes are separated by virtue of their solubility (log P) values in O/W MEEKC; with the more water-insoluble solutes migrating last. This separation process does not occur in W/O, as neutral solutes are not separated in order of log P.
引用
收藏
页码：645 / 652
页数：8
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