Phosphine-free thiopseudourea-Pd(II) complex catalyzed Larock heteroannulation of 2-haloamines with internal alkynes

被引：13

作者：

Srinivas, Keesara ^{[1
]}

Saiprathima, Parvathaneni ^{[1
]}

Balaswamy, Kodicherla ^{[1
]}

Rao, Mandapati Mohan ^{[1
]}

机构：

[1] Indian Inst Chem Technol, I & PC Div, Hyderabad 500607, Andhra Pradesh, India

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 741卷

关键词：

Thiopseudourea; Larock indolization; Phosphine free; Palladium; FISCHER INDOLE SYNTHESIS; 2,3-DISUBSTITUTED INDOLES; SOLID-PHASE; PALLADIUM; REACTIVITY; INDOLIZATION; HECK;

D O I：

10.1016/j.jorganchem.2013.05.049

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We examined the Pd-catalyzed heteroannulation of 2-haloamines with internal alkynes under phosphine-free conditions. The thiopseudourea palladium(II) complex (5) found to be an efficient catalyst for the Pd induced heteroannulation. Achieved high turnover number for the heteroannulation reactions of internal alkynes with 2-iodoaniline. A variety of 2-bromoanilines and N-tosyl substituted 2-bromoanilines effectively reacted with different substituted internal alkynes to give the corresponding indoles in good to high yields (1:1 ratio of regioisomers). (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：162 / 167

页数：6

共 30 条

[1] Regioselective Pd-catalyzed indolization of 2-bromoanilines with internal alkynes using phosphine-free ligands
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[2] Polystyrene supported thiopseudourea Pd(II) complex: Applications for Sonogashira, Suzuki-Miyaura, Heck, Hiyama and Larock heteroannulation reactions
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