Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects

被引:27
|
作者
Suman, OE
Beck, KC
Babcock, MA
Pegelow, DF
Reddan, WG
机构
[1] Mayo Clin & Mayo Fdn, Div Pulm & Crit Care Med, Thorac Dis Res Unit, Rochester, MN 55905 USA
[2] Univ Wisconsin, Dept Prevent Med, John Rakin Lab Pulm Med, Madison, WI 53706 USA
[3] Univ Wisconsin, Dept Med, Madison, WI 53706 USA
关键词
exercise-induced asthma; pulmonary resistance;
D O I
10.1152/jappl.1999.87.3.1107
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We compared pulmonary mechanics measured during long-term exercise (LTX = 20 min) with long-term isocapnic hyperventilation (LTIH = 20 min) in the same asthmatic individuals (n = 6). Peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) decreased during LTX (-19.7 and -22.0%, respectively) and during LTIH (-6.66 and 10.9%, respectively). In contrast, inspiratory pulmonary resistance (RLI) was elevated during LTX (57.6%) but not during LTIH (9.62%). As expected, airway function deteriorated post-LTX and post-LTIH (FEV1 = -30.2 and -21.2%; RLI = 111.8 and 86.5%, respectively). We conclude that the degree of airway obstruction observed during LTX is of a greater magnitude than that observed during LTIH. Both modes of hyperpnea induced similar levels of airway obstruction in the posthyperpnea period. However, the greater airway obstruction during LTX suggests that a different process may be responsible for the changes in airway function during and after the two modes of hyperpnea. This finding raises questions about the equivalency of LTIH and LTX in the study of airway function during exercise-induced asthma.
引用
收藏
页码:1107 / 1113
页数:7
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