NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection

被引：140
|
作者：
Alter, G. [1 ]
Altfeld, M. [1 ]
机构：
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA
来源：
JOURNAL OF INTERNAL MEDICINE | 2009年 / 265卷 / 01期
关键词：
HIV; innate immunity; Natural killer cells; viral immunity; NATURAL-KILLER-CELLS; CLASS-I MOLECULES; MHC CLASS-I; IMMUNODEFICIENCY VIRUS-INFECTION; DEPENDENT CELLULAR CYTOTOXICITY; HLA-B; DENDRITIC CELLS; INHIBITORY RECEPTORS; SELF-TOLERANCE; BINDING-SITE;
D O I：
10.1111/j.1365-2796.2008.02045.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increasing evidence supports the notion that the innate immune response, and in particular, natural killer cells play a central role in determining the quality of the host immune response to infection. In this review we highlight recent evidence that suggests that NK cells influence the clinical fate of HIV-infected individuals.
引用
收藏
页码：29 / 42
页数：14
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