Prognostic Factors for Survival of Patients with Extensive Stage Small Cell Lung Cancer - a Retrospective Single Institution Analysis

被引:19
|
作者
Wu, Chao [1 ]
Li, Fang [1 ]
Jiao, Shun-Chang [1 ]
机构
[1] Chinese PLA Peoples Liberat Army, Dept Gen Hosp, Beijing, Peoples R China
关键词
Small cell lung cancer; extensive stage; prognosis; liver metastasis; chemotherapy; ENOLASE NSE; MANAGEMENT;
D O I
10.7314/APJCP.2012.13.10.4959
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The objective of this retrospective study was to investigate prognostic factors associated with survival of patients with extensive stage small cell lung cancer (ES-SCLC). Included were 200 patients admitted to the Liberation Army General Hospital with a diagnosis of ES-SCLC. The demographics of patients, disease characteristics, pre-treatment biochemical parameters and therapeutic plan were assessed or evaluated. Univariate analysis found that second-line chemotherapy, radiotherapy, and no liver metastasis were associated with improved survival. Tumor response to first-line chemotherapy and normal initial hemoglobin levels were also associated with a survival benefit (all P-values <= 0.0369). Multivariate Cox regression analysis indicated that liver metastasis and the total number of all chemotherapy cycles were independent prognostic factors of survival. The morbidity risk in patients with liver metastasis was 2.52-fold higher than that in patients without liver metastasis (hazard ratio (HR)=2.52 (1.69-3.76); P<0.0001). However, one unit increase in the total number of chemotherapy cycles decreased the risk of death by 0.86-fold (HR=0.86 (0.80-0.92); P<0.0001). Absence of liver metastasis and ability of a patient to receive and tolerate multiple lines of chemotherapy were associated with longer survival.
引用
收藏
页码:4959 / 4962
页数:4
相关论文
共 50 条
  • [1] Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer - A retrospective single institution analysis
    Hermes, Andreas
    Gatzemeier, Ulrich
    Waschki, Benjamin
    Reck, Martin
    [J]. RESPIRATORY MEDICINE, 2010, 104 (12) : 1937 - 1942
  • [2] Outcomes and Prognostic Factors of Extensive Stage Small Cell Lung Cancer: A Retrospective Study
    Veena, P. S.
    Sajeed, A.
    Geethi, M. H.
    Krishna, K. M. Jagathnath
    Sivananadan, C. D.
    Sankar, S. Arun
    Roshni, S.
    Lijeesh, A. L.
    [J]. SOUTH ASIAN JOURNAL OF CANCER, 2023,
  • [3] Survival and pretreatment prognostic factors for extensive-stage small cell lung cancer: A comprehensive analysis of 358 patients
    Huang, Li-Ling
    Hu, Xing-Sheng
    Wang, Yan
    Li, Jun-Ling
    Wang, Hong-Yu
    Liu, Peng
    Xu, Jian-Ping
    He, Xiao-Hui
    Hao, Xue-Zhi
    Jiang, Pei-Di
    Liu, Yu-Tao
    Luo, Jian
    Zhou, Sheng-Yu
    Wang, Jin-Wan
    Yang, Jian-Liang
    Qin, Yan
    Yuan, Peng
    Lin, Lin
    Shi, Yuan-Kai
    [J]. THORACIC CANCER, 2021, 12 (13) : 1943 - 1951
  • [4] Prognostic factors for the survival of 66 cases with extensive stage-small cell lung cancer
    Heng Cao
    Yonggui Hong
    Shouran Zhao
    Nengchao Wang
    Fuyou Zhou
    Xiaodong Xie
    [J]. Oncology and Translational Medicine, 2016, 2 (01) : 12 - 15
  • [5] A retrospective analysis of prognostic factors for 160 patients with stage III small cell lung cancer
    Liu, Ying
    Xin, Ying
    Zhu, Jing
    Wang, Ying
    Dai, Xin-Ji
    Wei, Hua-Fang
    Zhang, Liang
    Cheng, Ying
    [J]. ANNALS OF PALLIATIVE MEDICINE, 2021, 10 (06) : 6189 - 6197
  • [6] Hyponatremia as prognostic factor in small cell lung cancer - A retrospective single institution analysis
    Hermes, Andreas
    Waschki, Benjamin
    Reck, Martin
    [J]. RESPIRATORY MEDICINE, 2012, 106 (06) : 900 - 904
  • [7] PROGNOSTIC FACTORS FOR EXTENSIVE STAGE SMALL CELL LUNG CANCER.
    Son, Choonhee
    Roh, Mee-Sook
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S931 - S931
  • [8] Prognostic Factors for Stage I Non Small Cell Lung Cancer: A Single Institution Experience
    Franzi, F.
    Imperatori, A.
    Rotolo, N.
    Dominioni, L.
    Capella, C.
    Sessa, F.
    [J]. LABORATORY INVESTIGATION, 2011, 91 : 409A - 410A
  • [9] Prognostic Factors for Stage I Non Small Cell Lung Cancer: A Single Institution Experience
    Franzi, F.
    Imperatori, A.
    Rotolo, N.
    Dominioni, L.
    Capella, C.
    Sessa, F.
    [J]. MODERN PATHOLOGY, 2011, 24 : 409A - 410A
  • [10] Clinical Prognostic Factors of Elderly Patients with Extensive Stage Small Cell Lung Cancer in Korea
    Kim, J. S.
    Choi, Y. J.
    Kang, E. J.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S2046 - S2047